Evidence map›Paper›PMID 34578350›Full record

ArticleViruses2021

Renewed Public Health Threat from Emerging Lyssaviruses.

Anthony R Fooks, Rebecca Shipley, Wanda Markotter, Noël Tordo, Conrad M Freuling, Thomas Müller, Lorraine M McElhinney, Ashley C Banyard, Charles E Rupprecht

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Minimal risk ofFrontiers in microbiology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. A rabies-related lyssavirus from aMicrobiology resource announcements · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. A One Medicine Mission for an Effective Rabies Therapy.Frontiers in veterinary science · 2022
    Article
  20. Rabies in the Tropics.Current tropical medicine reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Anthony R FooksAnimal and Plant Health Agency (APHA), WHO Collaborating Centre (Rabies)/OIE Reference Laboratory (Rabies), Weybridge KT15 3NB, UK.ORCID 0000-0002-3243-6154
Rebecca ShipleyAnimal and Plant Health Agency (APHA), WHO Collaborating Centre (Rabies)/OIE Reference Laboratory (Rabies), Weybridge KT15 3NB, UK.
Wanda MarkotterCentre for Viral Zoonoses, Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-7550-0080
Noël TordoInstitut Pasteur de Guinée, Route de Donka, Conakry BP 4416, Guinea.ORCID 0000-0001-5873-059X
Conrad M FreulingFriedrich-Loeffler-Institute (FLI), WHO Collaborating Centre for Rabies Surveillance and Research (Rabies)/OIE Reference Laboratory, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0002-1076-398X
Thomas MüllerFriedrich-Loeffler-Institute (FLI), WHO Collaborating Centre for Rabies Surveillance and Research (Rabies)/OIE Reference Laboratory, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0002-0959-3653
Lorraine M McElhinneyAnimal and Plant Health Agency (APHA), WHO Collaborating Centre (Rabies)/OIE Reference Laboratory (Rabies), Weybridge KT15 3NB, UK.ORCID 0000-0002-6022-348X
Ashley C BanyardAnimal and Plant Health Agency (APHA), WHO Collaborating Centre (Rabies)/OIE Reference Laboratory (Rabies), Weybridge KT15 3NB, UK.ORCID 0000-0002-1286-9825
Charles E RupprechtLYSSA LLC, Cumming, GA 30044, USA.
Animal and Plant Health Agency · GBFriedrich-Loeffler-Institut · DEInstitut de Recherche Agronomique de Guinée · GNUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen discovery contributes to our knowledge of bat-borne viruses and is linked to the heightened interest globally in bats as recognised reservoirs of zoonotic agents. The transmission of lyssaviruses from bats-to-humans, domestic animals, or other wildlife species is uncommon, but interest in these pathogens remains due to their ability to cause an acute, progressive, invariably fatal encephalitis in humans. Consequently, the detection and characterisation of bat lyssaviruses continues to expand our knowledge of their phylogroup definition, viral diversity, host species association, geographical distribution, evolution, mechanisms for perpetuation, and the potential routes of transmission. Although the opportunity for lyssavirus cross-species transmission seems rare, adaptation in a new host and the possibility of onward transmission to humans requires continued investigation. Considering the limited efficacy of available rabies biologicals it is important to further our understanding of protective immunity to minimize the threat from these pathogens to public health. Hence, in addition to increased surveillance, the development of a niche pan-lyssavirus vaccine or therapeutic biologics for post-exposure prophylaxis for use against genetically divergent lyssaviruses should be an international priority as these emerging lyssaviruses remain a concern for global public health.

Indexed as

Public HealthAnimalsChiropteraEncephalitisHumansItalyLyssavirusRabiesRhabdoviridae InfectionsZoonosesbatsemergingencephalitislyssavirusnovelprophylaxisrabieszoonoses

Identifiers

PMID34578350
PMCPMC8472001
OpenAlexW3196686271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.