Evidence map›Paper›PMID 34578323›Full record

ArticleViruses2021

Alterations in Brain Cannabinoid Receptor Levels Are Associated with HIV-Associated Neurocognitive Disorders in the ART Era: Implications for Therapeutic Strategies Targeting the Endocannabinoid System.

Mary K Swinton, Erin E Sundermann, Lauren Pedersen, Jacques D Nguyen, David J Grelotti, Michael A Taffe, Jennifer E Iudicello, Jerel Adam Fields

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  11. Effects of acute ΔBrain research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mary K SwintonDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Erin E SundermannDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Lauren PedersenDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Jacques D NguyenDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
David J GrelottiDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Michael A TaffeDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Jennifer E IudicelloDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.
Jerel Adam FieldsDepartment of Psychiatry, University of California, San Diego, CA 92093, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
The role of TREM2 in Alzheimer's disease neuropathogenesis in HIV+ individualsR56AG066215 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIELDS, JEREL ADAM · 2020 to 2020
$749k
Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapyK01MH115819 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIELDS, JEREL ADAM · 2018 to 2020
$480k
NIA NIH HHS R56 AG066215NIMHD NIH HHS L60 MD013161NIMH NIH HHS K01 MH115819NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

HIV-associated neurocognitive disorders (HAND) persist despite the advent of antiretroviral therapy (ART), suggesting underlying systemic and central nervous system (CNS) inflammatory mechanisms. The endogenous cannabinoid receptors 1 and 2 (CB

Indexed as

Anti-Inflammatory AgentsAstrocytesBrainCentral Nervous SystemEndocannabinoidsHIV InfectionsHumansImmunohistochemistryNeurocognitive DisordersNeurogliaReceptors, CannabinoidAnti-Inflammatory AgentsEndocannabinoidsReceptors, Cannabinoidastrocytescannabinoid receptorimmunohistochemistryinflammation

Identifiers

PMID34578323
PMCPMC8473156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.