Evidence map›Paper›PMID 34578292›Full record

ReviewViruses2021

Serological, Molecular and Culture-Based Diagnosis of Lentiviral Infections in Small Ruminants.

Aphrodite I Kalogianni, Ioannis Stavropoulos, Serafeim C Chaintoutis, Ioannis Bossis, Athanasios I Gelasakis

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  10. In vivo evaluation of the antiretroviral activity of Melia azedarach against small ruminant lentiviruses in goat colostrum and milk.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aphrodite I KalogianniLaboratory of Anatomy and Physiology of Farm Animals, Department of Animal Science, School of Animal Biosciences, Agricultural University of Athens (AUA), Iera Odos 75 Str., 11855 Athens, Greece.ORCID 0000-0002-1462-7432
Ioannis StavropoulosLaboratory of Animal Husbandry, Department of Agricultural Sciences, School of Agriculture, Forestry and Natural Resources, Aristotle University of Thessaloniki (AUTh), 54124 Thessaloniki, Greece.ORCID 0000-0002-4040-5737
Serafeim C ChaintoutisDiagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki (AUTh), 11 Stavrou Voutyra Str., 54627 Thessaloniki, Greece.ORCID 0000-0003-1539-8237
Ioannis BossisLaboratory of Animal Husbandry, Department of Agricultural Sciences, School of Agriculture, Forestry and Natural Resources, Aristotle University of Thessaloniki (AUTh), 54124 Thessaloniki, Greece.ORCID 0000-0002-8501-7586
Athanasios I GelasakisLaboratory of Anatomy and Physiology of Farm Animals, Department of Animal Science, School of Animal Biosciences, Agricultural University of Athens (AUA), Iera Odos 75 Str., 11855 Athens, Greece.ORCID 0000-0003-1144-3918
Aristotle University of Thessaloniki · GRAgricultural University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small ruminant lentiviruses (SRLVs) infections lead to chronic diseases and remarkable economic losses undermining health and welfare of animals and the sustainability of farms. Early and definite diagnosis of SRLVs infections is the cornerstone for any control and eradication efforts; however, a "gold standard" test and/or diagnostic protocols with extensive applicability have yet to be developed. The main challenges preventing the development of a universally accepted diagnostic tool with sufficient sensitivity, specificity, and accuracy to be integrated in SRLVs control programs are the genetic variability of SRLVs associated with mutations, recombination, and cross-species transmission and the peculiarities of small ruminants' humoral immune response regarding late seroconversion, as well as intermittent and epitope-specific antibody production. The objectives of this review paper were to summarize the available serological and molecular assays for the diagnosis of SRLVs, to highlight their diagnostic performance emphasizing on advantages and drawbacks of their application, and to discuss current and future perspectives, challenges, limitations and impacts regarding the development of reliable and efficient tools for the diagnosis of SRLVs infections.

Indexed as

AnimalsArthritis-Encephalitis Virus, CaprineGoat DiseasesGoatsLentivirusLentivirus InfectionsRuminantsSeroconversionSerologic TestsSheepSheep DiseasesVirologyVisna-maedi viruscaprine arthritis-encephalitiscell culturesdiagnosisELISAmaedi-visnamolecular methodsPCRserological methodssmall ruminant lentiviruses

Identifiers

PMID34578292
PMCPMC8473411
OpenAlexW3197452373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.