Evidence map›Paper›PMID 34578229›Full record

ArticlePathogens (Basel, Switzerland)2021

Immunobiotic Lactobacilli Improve Resistance of Respiratory Epithelial Cells to SARS-CoV-2 Infection.

Md Aminul Islam, Leonardo Albarracin, Mikado Tomokiyo, Juan Carlos Valdez, Jacinto Sacur, Maria Guadalupe Vizoso-Pinto, Bruno G N Andrade, Rafael R C Cuadrat, Haruki Kitazawa, Julio Villena

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Live and heat-treatediScience · 2026
    Article
  4. Nutrients · 2026
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  5. CombinedInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Enhancing Resistance toNutrients · 2025
    Article
  8. Article
  9. Frontiers in cellular and infection microbiology · 2025
    Article
  10. Article
  11. Article
  12. Microorganisms · 2022
    Article
  13. Review
  14. The Beneficial Role of ProbioticFrontiers in immunology · 2022
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Md Aminul IslamFood and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.ORCID 0000-0003-1979-9652
Leonardo AlbarracinLaboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina.
Mikado TomokiyoFood and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.
Juan Carlos ValdezLaboratory of Immunology, Faculty of Biochemistry, Chemistry and Pharmacy, National University of Tucuman, Tucuman 4000, Argentina.
Jacinto SacurInfection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucuman 4000, Argentina.ORCID 0000-0002-0514-5087
Maria Guadalupe Vizoso-PintoInfection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucuman 4000, Argentina.
Bruno G N AndradeAdaptCentre, Munster Technological University (MTU), T12 P928 Cork, Ireland.
Rafael R C CuadratMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), 13125 Berlin, Germany.ORCID 0000-0001-8289-2599
Haruki KitazawaFood and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.ORCID 0000-0003-4586-5553
Julio VillenaFood and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.ORCID 0000-0003-4941-4960
Consejo Nacional de Investigaciones Científicas y Técnicas · ARTohoku University · JPMax Delbrück Center · DEMunster Technological University · IENational University of Tucumán · AR

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT-2016-0410Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (A) (19H00965
6 · The paper itself

Abstract

Previously, we reported that immunomodulatory lactobacilli, nasally administered, beneficially regulated the lung antiviral innate immune response induced by Toll-like receptor 3 (TLR3) activation and improved protection against the respiratory pathogens, influenza virus and respiratory syncytial virus in mice. Here, we assessed the immunomodulatory effects of viable and non-viable

Indexed as

coronavirusCOVID-19immunobioticsLactiplantibacillus plantarumprobioticsrespiratory epithelial cellsSARS-CoV-2TLR3

Identifiers

PMID34578229
PMCPMC8472143
OpenAlexW3199548395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.