Coevolved Multidrug-Resistant HIV-1 Protease and Reverse Transcriptase Influences Integrase Drug Susceptibility and Replication Fitness.

Supang A Martin, Patricia A Cane, Deenan Pillay, Jean L Mbisa

Open access · goldAbstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.1field-weighted citation impact, top 51% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

Structure-based pharmacophore modeling, high-throughput screening, and molecular dynamics identify a novel DrugBank-derived HIV-1 protease inhibitor.PloS one · 2026
Article
Effects of Korean Red Ginseng combination therapy on HIV-infected patients treated with integrase strand transfer inhibitors.Journal of ginseng research · 2024
Article
Current Research on HIV Drug Resistance-A Topical Collection with "Pathogens (Basel, Switzerland) · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Supang A MartinAntiviral Unit, Virus Reference Department, Public Health England, London NW9 5EQ, UK.

Patricia A CaneAntiviral Unit, Virus Reference Department, Public Health England, London NW9 5EQ, UK.

Deenan PillayDivision of Infection and Immunity, University College London, London WC1E 6BT, UK.

Jean L MbisaAntiviral Unit, Virus Reference Department, Public Health England, London NW9 5EQ, UK.ORCID 0000-0002-0348-9679

Public Health England · GBUniversity College London · GB

Funding

Public Health England PhD Studentship

6 · The paper itself

Abstract

Integrase strand transfer inhibitors (InSTIs) are recommended agents in first-line combination antiretroviral therapy (cART). We examined the evolution of drug resistance mutations throughout HIV-1

Indexed as

drug resistanceHIV-1integrase strand transfer inhibitorsreplication fitnesssingle genome sequencing

Identifiers

PMID34578103

DOI10.3390/pathogens10091070

PMCPMC8470981

OpenAlexW3194150935

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.