Evidence map›Paper›PMID 34578074›Full record

ArticlePolymers2021

Ciprofibrate-Loaded Nanoparticles Prepared by Nanoprecipitation: Synthesis, Characterization, and Drug Release.

Raissa Lohanna Gomes Quintino Corrêa, Renan Dos Santos, Lindomar José Calumby Albuquerque, Gabriel Lima Barros de Araujo, Charlotte Jennifer Chante Edwards-Gayle, Fabio Furlan Ferreira, Fanny Nascimento Costa

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Raissa Lohanna Gomes Quintino CorrêaCenter for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André 09210-580, Brazil.ORCID 0000-0002-7584-9354
Renan Dos SantosCenter for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André 09210-580, Brazil.
Lindomar José Calumby AlbuquerqueCenter for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André 09210-580, Brazil.ORCID 0000-0003-1443-1795
Gabriel Lima Barros de AraujoDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
Charlotte Jennifer Chante Edwards-GayleDiamond Light Source, Harwell Science & Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.
Fabio Furlan FerreiraCenter for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André 09210-580, Brazil.ORCID 0000-0003-1516-1221
Fanny Nascimento CostaCenter for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André 09210-580, Brazil.ORCID 0000-0001-9368-5640
Diamond Light Source · GBUniversidade Federal do ABC · BRBrazilian Synchrotron Light Laboratory · BRNanomed (Brazil) · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307664/2015-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/23844-8
6 · The paper itself

Abstract

Ciprofibrate (CIP) is a highly lipophilic and poorly water-soluble drug, typically used for dyslipidemia treatment. Although it is already commercialized in capsules, no previous studies report its solid-state structure; thus, information about the correlation with its physicochemical properties is lacking. In parallel, recent studies have led to the improvement of drug administration, including encapsulation in polymeric nanoparticles (NPs). Here, we present CIP's crystal structure determined by PXRD data. We also propose an encapsulation method for CIP in micelles produced from Pluronic P123/F127 and PEO-

Indexed as

ciprofibratecrystallographydrug deliverynanotechnologyRietveld method

Identifiers

PMID34578074
PMCPMC8468397
OpenAlexW3200019817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.