Evidence map›Paper›PMID 34577857›Full record

ArticleMedicina (Kaunas, Lithuania)2021

The Prognostic Significance of MACC1 Expression in Breast Cancer and Its Relationship to Immune Cells in the Tumor Microenvironment and Patient Survival.

Dina A Ali, Dina M El-Guindy, Mohamed A Elrashidy, Nesreen M Sabry, Ahmed M Kabel, Rasha A Gaber, Rowida R Ibrahim, Sara M Samy, Marwa M Shalaby, Samir A Salama and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. MACC1 in colorectal cancer: a claim-level evidence audit from metastasis driver to proposed microenvironmental regulator.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Prognostic Significance ofIranian journal of biotechnology · 2025
    Article
  3. Prognostic risk stratification value of MACC1 expression in patients with gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Dina A AliClinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Dina M El-GuindyPathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0003-3419-0618
Mohamed A ElrashidyPathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Nesreen M SabryClinical Oncology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0001-5458-3422
Ahmed M KabelPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0002-5101-8011
Rasha A GaberMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Rowida R IbrahimMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Sara M SamyMedical Microbiology and Immunology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Marwa M ShalabyMedical Microbiology and Immunology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Samir A SalamaDivision of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Dina AbdelhaiClinical Pathology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Tanta University · EGTaif University · SA

Funding

Taif University TURSP-2020/52
6 · The paper itself

Abstract

Breast cancer (BC) is one of the most prevalent malignancies among females worldwide. Globally, distant metastases were reported to be responsible for a large proportion of breast cancer-related deaths. The metastasis-associated colon cancer-1 (MACC1) gene was reported as a reliable biomarker for early detection of metastasis and prediction of prognosis of breast cancer. This study investigated the prognostic significance of MACC1 in breast cancer in relation to the clinicopathologic characteristics and patients' survival. Furthermore, the possible correlation between MACC1 expression and the different immune cells in the tumor microenvironment was explored. MACC1 mRNA was identified using quantitative reverse transcription polymerase chain reaction in 120 breast cancer specimens and adjacent non-cancerous tissues. MACC1 mRNA expression was significantly higher in the cancerous relative to the non-cancerous tissues (

Indexed as

Breast NeoplasmsColonic NeoplasmsBiomarkers, TumorFemaleHumansPrognosisTrans-ActivatorsTranscription FactorsTumor MicroenvironmentBiomarkers, TumorMACC1 protein, humanTrans-ActivatorsTranscription Factorsbreast cancerCD163+ tumor-associated macrophagesCD56+ natural killer cellsCD8+ cytotoxic T lymphocytesmetastasis-associated colon cancer-1

Identifiers

PMID34577857
PMCPMC8466860
OpenAlexW3197519913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.