ReviewMicromachines2021
Polymer-Based Biocompatible Packaging for Implantable Devices: Packaging Method, Materials, and Reliability Simulation.
Review in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Subdermal Insertable Sensors for Health Monitoring: Applications, Challenges, and Emerging Technologies.Annals of biomedical engineering · 2026Review
- Technological Advances and Medical Applications of Implantable Electronic Devices: From the Heart, Brain, and Skin to Gastrointestinal Organs.Biosensors · 2025Review
- Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording.Microsystems & nanoengineering · 2025Article
- Conducting Polymers-Based Gas Sensors: Principles, Materials, and Applications.Sensors (Basel, Switzerland) · 2025Review
- Repackaging and Performance Analysis of Implantable Pressure Sensor.Sensors (Basel, Switzerland) · 2025Article
- Structure and Properties of Poly(Ethylene-co-vinyl Acetate) Nanocomposites with Dual-Functionalized Dolomite Nanoparticles.International journal of molecular sciences · 2024Article
- Editorial for the Special Issue on Wearable and Implantable Bio-MEMS Devices and Applications.Micromachines · 2024Article
- Flexible high-density microelectrode arrays for closed-loop brain-machine interfaces: a review.Frontiers in neuroscience · 2024Review
- Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response.Bioengineering (Basel, Switzerland) · 2023Review
- Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating.Scientific reports · 2023Article
- Mechanical Characterization and Analysis of Different-Type Polyimide Feedthroughs Based on Tensile Test and FEM Simulation for an Implantable Package.Micromachines · 2022Article
- Editorial for the Special Issue "MEMS Packaging Technologies and 3D Integration".Micromachines · 2022Article
- Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation.RSC advances · 2022Review
- A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation.Micromachines · 2022Article
- Research on the Factors Damaging Hydrogen Peroxide Low-Temperature Plasma Sterile Packaging Bags and the Control of Link Quality.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymer materials attract more and more interests for a biocompatible package of novel implantable medical devices. Medical implants need to be packaged in a biocompatible way to minimize FBR (Foreign Body Reaction) of the implant. One of the most advanced implantable devices is neural prosthesis device, which consists of polymeric neural electrode and silicon neural signal processing integrated circuit (IC). The overall neural interface system should be packaged in a biocompatible way to be implanted in a patient. The biocompatible packaging is being mainly achieved in two approaches; (1) polymer encapsulation of conventional package based on die attach, wire bond, solder bump, etc. (2) chip-level integrated interconnect, which integrates Si chip with metal thin film deposition through sacrificial release technique. The polymer encapsulation must cover different materials, creating a multitude of interface, which is of much importance in long-term reliability of the implanted biocompatible package. Another failure mode is bio-fluid penetration through the polymer encapsulation layer. To prevent bio-fluid leakage, a diffusion barrier is frequently added to the polymer packaging layer. Such a diffusion barrier is also used in polymer-based neural electrodes. This review paper presents the summary of biocompatible packaging techniques, packaging materials focusing on encapsulation polymer materials and diffusion barrier, and a FEM-based modeling and simulation to study the biocompatible package reliability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.