Evidence map›Paper›PMID 34577559›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Biodegradable Zinc Oxide Nanoparticles Doped with Iron as Carriers of Exogenous Iron in the Living Organism.

Paula Kiełbik, Aneta Jończy, Jarosław Kaszewski, Mikołaj Gralak, Julita Rosowska, Rafał Sapierzyński, Bartłomiej Witkowski, Łukasz Wachnicki, Krystyna Lawniczak-Jablonska, Piotr Kuzmiuk and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Paula KiełbikInstitute of Veterinary Medicine, Department of Physiological Sciences, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.ORCID 0000-0002-6069-6201
Aneta JończyInstitute of Genetics and Animal Biotechnology, Department of Molecular Biology, Polish Academy of Sciences (PAS), 05-552 Jastrzębiec, Poland.
Jarosław KaszewskiInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Mikołaj GralakInstitute of Veterinary Medicine, Department of Physiological Sciences, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Julita RosowskaInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Rafał SapierzyńskiDivision of Pathology, Institute of Veterinary Medicine, Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences, 02-776 Warsaw, Poland.
Bartłomiej WitkowskiInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.ORCID 0000-0003-0108-6902
Łukasz WachnickiInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Krystyna Lawniczak-JablonskaInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Piotr KuzmiukInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Paweł LipińskiInstitute of Genetics and Animal Biotechnology, Department of Molecular Biology, Polish Academy of Sciences (PAS), 05-552 Jastrzębiec, Poland.ORCID 0000-0002-0121-4460
Marek GodlewskiInstitute of Physics, Polish Academy of Sciences (PAS), 02-668 Warsaw, Poland.
Michał Marek GodlewskiInstitute of Veterinary Medicine, Department of Physiological Sciences, Warsaw University of Life Sciences, 02-787 Warsaw, Poland.
Institute of Physics · PLWarsaw University of Life Sciences · PLPolish Academy of Sciences · PL

Funding

Narodowe Centrum Nauki 2017/27/N/NZ4/01219
6 · The paper itself

Abstract

Iron plays an important role in various crucial processes in the body and its deficiency is considered currently as a serious health problem. Thus, iron supplementation strategies for both humans and animals need to be effective and safe. According to our previous studies, zinc-based nanoparticles provide safe, biodegradable, fast and efficient transport system of orally given substances to the tissues. In the current manuscript we present results of a study aimed at investigation of the ZnO nanoparticle-based Fe supplementation system (average size 100 × 250 nm). Nanostructures were orally (gavage) administered to adult mice. Animals were sacrificed at different time points with collection of blood and internal organs for analyses (tissue iron concentration, hepatic level of hepcidin, blood parameters, liver and spleen levels of ferritin, histopathology). Initial experiment was performed to compare the biological effect of doping type (Fe

Indexed as

anemiahepcidiniron deficiencyiron deliveryiron oxide nanoparticlesnanotechnologyoral iron

Identifiers

PMID34577559
PMCPMC8472157
OpenAlexW3197891990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.