Evidence map›Paper›PMID 34577194›Full record

ArticleMolecules (Basel, Switzerland)2021

In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2.

Seyyed Sasan Mousavi, Akbar Karami, Tahereh Movahhed Haghighi, Sefren Geiner Tumilaar, Fatimawali, Rinaldi Idroes, Shafi Mahmud, Ismail Celik, Duygu Ağagündüz, Trina Ekawati Tallei and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Biochemistry research international · 2025
    Article
  7. Article
  8. Bioprospection ofInternational journal of medical sciences · 2025
    Article
  9. Article
  10. Article
  11. Evaluation of the Antidiabetic Activities of the Fruit ofBioinformatics and biology insights · 2024
    Review
  12. Article
  13. Article
  14. Preliminary Evaluation ofACS omega · 2023
    Article
  15. Article
  16. Article
  17. Molecular Modeling Identification of Key Secondary Metabolites fromEvidence-based complementary and alternative medicine : eCAM · 2023
    Article
  18. In silico Screening of Potential SARS-CoV-2 Main Protease Inhibitors fromAdvances and applications in bioinformatics and chemistry : AABC · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seyyed Sasan MousaviDepartment of Horticultural Science, School of Agriculture, Shiraz University, Shiraz 71441, Iran.
Akbar KaramiDepartment of Horticultural Science, School of Agriculture, Shiraz University, Shiraz 71441, Iran.ORCID 0000-0002-7800-5472
Tahereh Movahhed HaghighiDepartment of Horticultural Science, School of Agriculture, Shiraz University, Shiraz 71441, Iran.ORCID 0000-0002-2796-979X
Sefren Geiner TumilaarPharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
FatimawaliPharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia.
Rinaldi IdroesDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh 23111, Indonesia.ORCID 0000-0003-2264-6358
Shafi MahmudMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0000-0003-1604-8626
Ismail CelikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey.
Duygu AğagündüzDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey.ORCID 0000-0003-0010-0012
Trina Ekawati TalleiThe University Center of Excellence for Biotechnology and Conservation of Wallacea, Sam Ratulangi University, Manado 95115, Indonesia.
Talha Bin EmranDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.ORCID 0000-0003-3188-2272
Raffaele CapassoDepartment of Agricultural Sciences, University of Naples Federico II, Portici, 80055 Naples, Italy.ORCID 0000-0002-3335-1822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially appeared in Wuhan, China, in December 2019. Elderly individuals and those with comorbid conditions may be more vulnerable to this disease. Consequently, several research laboratories continue to focus on developing drugs to treat this infection because this disease has developed into a global pandemic with an extremely limited number of specific treatments available. Natural herbal remedies have long been used to treat illnesses in a variety of cultures. Modern medicine has achieved success due to the effectiveness of traditional medicines, which are derived from medicinal plants. The objective of this study was to determine whether components of natural origin from Iranian medicinal plants have an antiviral effect that can prevent humans from this coronavirus infection using the most reliable molecular docking method; in our case, we focused on the main protease (M

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsComputer SimulationHumansIranMolecular Docking SimulationMolecular Dynamics SimulationPeptide HydrolasesPhytochemicalsPlants, MedicinalProtease InhibitorsProtein BindingReceptors, VirusSARS-CoV-2ThermodynamicsViral Protease InhibitorsAntiviral AgentsPeptide HydrolasesPhytochemicalsProtease InhibitorsReceptors, VirusViral Protease Inhibitorschelidimerinecoronavirusinhibitormain proteasemedicinal plantmolecular dockingmolecular dynamics simulationreceptor-binding domain

Identifiers

PMID34577194
PMCPMC8470205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.