ReviewMolecules (Basel, Switzerland)2021
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 45 citations in OpenAlex.
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- Bis-Oxadiazole Assemblies as NO-Releasing Anticancer Agents.Pharmaceutics · 2025Article
- Hydrophobic Drug Delivery Platforms Based on Covalent Organic Frameworks for Combined Treatment of Alzheimer's Disease.International journal of molecular sciences · 2025Article
- Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury.BMC neuroscience · 2025Article
- Sustainable electrochemical synthesis of aliphatic nitro-Beilstein journal of organic chemistry · 2025Article
- Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria.Advanced healthcare materials · 2024Article
- Ammonium Dinitramide as a Prospective N-NOMolecules (Basel, Switzerland) · 2024Article
- Optimization of the 2-arylquinazoline-4(3RSC medicinal chemistry · 2023Article
- Regioselective Synthesis of NO-Donor (4-Nitro-1,2,3-triazolyl)furoxans via Eliminative Azide-Olefin Cycloaddition.Molecules (Basel, Switzerland) · 2023Article
- Unlocking Kuhn Verdazyls: New Synthetic Approach and Useful Mechanistic Insights.International journal of molecular sciences · 2023Article
- Article
- Mesoionic Imines (MIIs): Strong Donors and Versatile Ligands for Transition Metals and Main Group Substrates.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.
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