Evidence map›Paper›PMID 34577145›Full record

ArticleMolecules (Basel, Switzerland)2021

In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on

Raiza B Peres, Ludmila F de A Fiuza, Patrícia B da Silva, Marcos M Batista, Flávia da C Camillo, André M Marques, Lavínia de C Brito, Maria R Figueiredo, Maria de N C Soeiro

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Phenotypic Analysis of the Anti-Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Semisynthetic Ecdysteroid Cinnamate Esters andJournal of natural products · 2024
    Article
  6. Article
  7. Antiparasitic Activity ofPharmaceutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raiza B PeresLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Ludmila F de A FiuzaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Patrícia B da SilvaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Marcos M BatistaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Flávia da C CamilloLaboratório de Tecnologia para Biodiversidade em Saúde/LDFito, Instituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
André M MarquesLaboratório de Tecnologia para Biodiversidade em Saúde/LDFito, Instituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Lavínia de C BritoLaboratório de Tecnologia para Biodiversidade em Saúde/LDFito, Instituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Maria R FigueiredoLaboratório de Tecnologia para Biodiversidade em Saúde/LDFito, Instituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.
Maria de N C SoeiroLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 210360-040, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302160/2019-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 400043/2017-3Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro CNEFundação Oswaldo Cruz PAEF
6 · The paper itself

Abstract

Chagas disease (CD) affects more than 6 million people worldwide. The available treatment is far from ideal, creating a demand for new alternative therapies. Botanical diversity provides a wide range of novel potential therapeutic scaffolds. Presently, our aim was to evaluate the mammalian host toxicity and anti-

Indexed as

BiodiversityBiological ProductsPlant ExtractsTrypanocidal AgentsTrypanosoma cruziAnimalsBrazilChagas DiseaseComputer SimulationBiological ProductsPlant ExtractsTrypanocidal AgentsaurelianolidesChagas diseasesin silico ADMETnatural productsT. cruziwithanolides

Identifiers

PMID34577145
PMCPMC8472459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.