Evidence map›Paper›PMID 34577079›Full record

ArticleMolecules (Basel, Switzerland)2021

Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues.

Jilan A Nazeam, Ghada M Ragab, Amira A El-Gazar, Shereen S El-Mancy, Lina Jamil, Sahar M Fayez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jilan A NazeamPharmacognosy Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.ORCID 0000-0003-1149-8222
Ghada M RagabPharmacology and Toxicological Department, Faculty of Pharmacy, Misr University, Giza 12585, Egypt.
Amira A El-GazarPharmacology and Toxicological Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.ORCID 0000-0002-8372-4682
Shereen S El-MancyPharmaceutics Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.ORCID 0000-0001-8151-6778
Lina JamilMicrobiology and Immunology Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.
Sahar M FayezPharmaceutics Department, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.ORCID 0000-0002-0001-6147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a dramatic global threat; however, the slow progress of new antibiotic development has impeded the identification of viable alternative strategies. Natural antioxidant-based antibacterial approaches may provide potent therapeutic abilities to effectively block resistance microbes' pathways. While essential oils (EOs) have been reported as antimicrobial agents, its application is still limited ascribed to its low solubility and stability characters; additionally, the related biomolecular mechanisms are not fully understood. Hence, the study aimed to develop a nano-gel natural preparation with multiple molecular mechanisms that could combat bacterial resistance in an

Indexed as

Acne VulgarisAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsBehavior, AnimalBiofilmsCuesForkhead Transcription FactorsInsulin-Like Growth Factor IInterleukin-6NanogelsNF-kappa BPlant ExtractsPolyethylene GlycolsPolyethyleneiminePPAR gammaAnti-Bacterial AgentsAnti-Inflammatory AgentsForkhead Transcription FactorsInsulin-Like Growth Factor IInterleukin-6NanogelsNF-kappa BPlant Extractspolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneiminePPAR gammaToll-Like Receptor 2Transforming Growth Factor betaWnt ProteinsantibioticBacillus thuringiensisclinical bacterial isolatecloveEnterococcus faeciumessential oilIGF-1nanogelnon-antibioticPPAR γPseudomonas stutzeriskin infectionthyme

Identifiers

PMID34577079
PMCPMC8465895

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.