Evidence map›Paper›PMID 34577027›Full record

ArticleMolecules (Basel, Switzerland)2021

Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.

Juan Chen, Yixuan Chen, Yangfan Zheng, Jiawen Zhao, Huilin Yu, Jiajin Zhu, Duo Li

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Fraction ofThe journal of venomous animals and toxins including tropical diseases · 2024
    Article
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  7. Article
  8. Article
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  11. Protective Effect ofMolecules (Basel, Switzerland) · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Juan ChenDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Yixuan ChenDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Yangfan ZhengDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Jiawen ZhaoDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Huilin YuDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Jiajin ZhuDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.
Duo LiDepartment of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.ORCID 0000-0001-5227-5565
Zhejiang University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research assessed the molecular mechanism of procyanidins (PCs) against neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium (MPP

Indexed as

AntioxidantsParkinson DiseaseProanthocyanidinsReactive Oxygen SpeciesZebrafish1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAnimalsBiflavonoidsCatechinDisease Models, AnimalNeuroprotective AgentsNF-E2-Related Factor 2Oxidative StressPC12 CellsRats1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAntioxidantsBiflavonoidsCatechinNeuroprotective AgentsNF-E2-Related Factor 2ProanthocyanidinsprocyanidinReactive Oxygen SpeciesSuperoxide DismutaseNrf2/ARE pathwayParkinson’s diseasePC12 cellsprocyanidinszebrafish

Identifiers

PMID34577027
PMCPMC8464719
OpenAlexW3200833022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.