Oxazinethione Derivatives as a Precursor to Pyrazolone and Pyrimidine Derivatives: Synthesis, Biological Activities, Molecular Modeling, ADME, and Molecular Dynamics Studies.

Magda H Abdellattif, Mohd Shahbaaz, M M H Arief, Mostafa A Hussien

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies.ACS omega · 2024
Article
Synthesis of novel pyrazolone candidates with studying some biological activities and in-silico studies.Scientific reports · 2023
Article
Molecular Modeling and Synthesis of Indoline-2,3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase Enzymes.ACS omega · 2023
Article
New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties.Pharmaceuticals (Basel, Switzerland) · 2022
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Magda H AbdellattifDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Mohd ShahbaazSouth African Medical Research Council Bioinformatics Institute, University of Western Cape, Private Bag X17, Bellville, Cape Town 7535, South Africa.

M M H AriefChemistry Department, Faculty of Science, Benha University, Benha 13511, Egypt.

Mostafa A HussienDepartment of Chemistry, Faculty of Science, Port Said University, Port Said 42521, Egypt.ORCID 0000-0002-4803-167X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we used oxazinethione as a perfect precursor to synthesize new pyrimidine and pyrazole derivatives with potent biological activities. Biological activities were determined for all compounds against

Indexed as

Anti-Infective AgentsAntineoplastic AgentsCell Line, TumorEscherichia coliFemaleHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureOxazinesPyrazolonesPyrimidinesStaphylococcus aureusAnti-Infective AgentsAntineoplastic AgentsOxazinespyrazolonePyrazolonesPyrimidinesADMEmolecular dockingone-pot synthesisoxazinespyrazolepyrimidine

Identifiers

PMID34576953

DOI10.3390/molecules26185482

PMCPMC8468439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.