Evidence map›Paper›PMID 34576952›Full record

ArticleMolecules (Basel, Switzerland)2021

The Effect of Different Ester Chain Modifications of Two Guaianolides for Inhibition of Colorectal Cancer Cell Growth.

Lamis Al Aaraj, Berthe Hayar, Zaynab Jaber, Walid Saad, Najat A Saliba, Nadine Darwiche, Tarek Ghaddar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Dichloromethane fractions ofMolecular medicine reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lamis Al AarajAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
Berthe HayarAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.ORCID 0000-0002-4910-0032
Zaynab JaberAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.ORCID 0000-0001-8931-8936
Walid SaadAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
Najat A SalibaAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.ORCID 0000-0002-4276-1524
Nadine DarwicheAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.ORCID 0000-0002-1862-5426
Tarek GhaddarAUB Nature Conservation Center, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
American University of Beirut · LB

Funding

Hikma Pharmaceuticals N/A
6 · The paper itself

Abstract

Several sesquiterpene lactones (STLs) have been tested as lead drugs in cancer clinical trials. Salograviolide-

Indexed as

Antineoplastic Agents, PhytogenicCentaureaColorectal NeoplasmsCysteineDrug Screening Assays, AntitumorHCT116 CellsHeterocyclic Compounds, 3-RingHumansPlants, MedicinalStructure-Activity RelationshipAntineoplastic Agents, PhytogenicCysteineHeterocyclic Compounds, 3-Ringsalograviolide Acell growth activitycolorectal cancerester derivativesguaianolidesp53sesquiterpene lactones

Identifiers

PMID34576952
PMCPMC8469367
OpenAlexW3197323482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.