ArticleMolecules (Basel, Switzerland)2021
Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives.
Sandra Piras, Gabriele Murineddu, Giovanni Loriga, Antonio Carta, Enrica Battistello, Stefania Merighi, Stefania Gessi, Paola Corona, Battistina Asproni, Roberta Ibba and 3 more
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors at 4 institutions in 2 countries.
Sandra PirasDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.
Gabriele MurinedduDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.ORCID 0000-0002-2791-9178 Giovanni LorigaInstitute of Biomolecular Chemistry, National Research Council, Traversa La Crucca 3, 07100 Sassari, Italy.
Antonio CartaDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.
Enrica BattistelloDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Stefania MerighiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0839-6671 Stefania GessiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Paola CoronaDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.ORCID 0000-0002-9182-478X Battistina AsproniDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.ORCID 0000-0002-0988-1882 Roberta IbbaDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.ORCID 0000-0003-3332-3845 Veronika TemmlDepartment of Pharmaceutical Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria.ORCID 0000-0001-7662-9882 Daniela SchusterDepartment of Pharmaceutical Chemistry, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria.ORCID 0000-0002-9933-8938 Gérard Aimè PinnaDepartment of Chemistry and Pharmacy, University of Sassari, via F. Muroni 23/A, 07100 Sassari, Italy.
University of Sassari · ITUniversity of Ferrara · ITParacelsus Medical University · ATNational Research Council · IT
Funding
Austrian Science Fund FWF T 942
6 · The paper itselfAbstract
Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists, μ-agonists are the only ones used in therapy. Previously synthesized compounds with diazotricyclodecane cores (DTDs) have shown their effectiveness in binding opioid receptors. Fourteen novel diazatricyclodecanes belonging to the 9-propionyl-10-substituted-9,10-diazatricyclo[4.2.1.1
Indexed as
Receptors, Opioid, muAnalgesics, OpioidAnimalsHumansMolecular StructureProtein BindingReceptors, Opioid, kappaStructure-Activity RelationshipAnalgesics, OpioidReceptors, Opioid, kappaReceptors, Opioid, mu2,7-diazatricyclo[4.4.0.03,8]decane9,10-diazatricyclo[4.2.1.12,5]decane (DTD)analgesic activityDTD derivativesrigid benzo-condensed structureμ-receptors affinity
Identifiers
PMID34576918
PMCPMC8467848
OpenAlexW3196550441
What OpenQuestion holds
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LicenceCC BY
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