Evidence map›Paper›PMID 34576905›Full record

ArticleMolecules (Basel, Switzerland)2021

Antinociceptive Synergism of Pomegranate Peel Extract and Acetylsalicylic Acid in an Animal Pain Model.

José Antonio Guerrero-Solano, Mirandeli Bautista, Claudia Velázquez-González, Minarda De la O-Arciniega, Luis Guillermo González-Olivares, Monserrat Fernández-Moya, Osmar Antonio Jaramillo-Morales

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Bioguided Isolation of (Pharmaceutics · 2026
    Article
  3. Beneficial Effects of Pomegranate Extracts for Benign Gynecologic Disorders.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  4. Targeting L-arginine/NO/cGMP/KFrontiers in pharmacology · 2025
    Review
  5. Article
  6. Antimicrobial efficacy ofFrontiers in microbiology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

José Antonio Guerrero-SolanoInstitute of Health Sciences, Academic Area of Pharmacy, Autonomous University of the State of Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca Actopan, San Agustín Tlaxiaca, Hidalgo 42160, Mexico.ORCID 0000-0002-9331-9509
Mirandeli BautistaInstitute of Health Sciences, Academic Area of Pharmacy, Autonomous University of the State of Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca Actopan, San Agustín Tlaxiaca, Hidalgo 42160, Mexico.ORCID 0000-0002-6725-270X
Claudia Velázquez-GonzálezInstitute of Health Sciences, Academic Area of Pharmacy, Autonomous University of the State of Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca Actopan, San Agustín Tlaxiaca, Hidalgo 42160, Mexico.
Minarda De la O-ArciniegaInstitute of Health Sciences, Academic Area of Pharmacy, Autonomous University of the State of Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca Actopan, San Agustín Tlaxiaca, Hidalgo 42160, Mexico.ORCID 0000-0002-5765-1950
Luis Guillermo González-OlivaresInstitute of Basic Sciences and Engineering, Academic Area of Chemistry, University of the State of Hidalgo, Carretera Pachuca-Tulancingo km 4.5 s/n, Mineral de la Reforma, Hidalgo 42184, Mexico.ORCID 0000-0002-4707-8935
Monserrat Fernández-MoyaLife Sciences Division, Nursing and Obstetrics Department, Campus Irapuato-Salamanca, University of Guanajuato, Ex Hacienda el Copal, km. 9 Carretera Irapuato- Silao, A.P. 311, Irapuato, Guanajuato 36500, Mexico.
Osmar Antonio Jaramillo-MoralesLife Sciences Division, Nursing and Obstetrics Department, Campus Irapuato-Salamanca, University of Guanajuato, Ex Hacienda el Copal, km. 9 Carretera Irapuato- Silao, A.P. 311, Irapuato, Guanajuato 36500, Mexico.ORCID 0000-0002-5325-3760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several modern drugs, which are derived from traditional herbal medicine are used in contemporary pharmacotherapy. Currently, the study of drug-plant interactions in pain has increased in recent years, looking for greater efficacy of the drug and reduce side effects. The antinociception induced by intragastric co-administration of the combination of pomegranate peel extract (PoPEx) and acetylsalicylic acid (ASA) was assessed using the isobolographic analysis in formalin test (nociceptive and inflammatory pain). The effective dose that produced 30% of antinociception (ED

Indexed as

AnalgesicsAspirinDisease Models, AnimalDrug SynergismPlant ExtractsPomegranateAnimalsAntioxidantsMaleMiceNitric OxidePainAnalgesicsAntioxidantsAspirinNitric OxidePlant Extractsacetylsalicylic acidantinociceptivecombinationformalin testisobologrampainpomegranate peelPunica granatum L.synergism

Identifiers

PMID34576905
PMCPMC8469324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.