Evidence map›Paper›PMID 34576859›Full record

ReviewMicroorganisms2021

COVID-19 Infection in Children, Infants and Pregnant Subjects: An Overview of Recent Insights and Therapies.

Giuseppina Malcangi, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Luigi Santacroce, Grazia Marinelli, Antonio Mancini, Luigi Vimercati, Maria Elena Maggiore, Maria Teresa D'Oria, Denisa Hazballa and 16 more

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 3 countries.

Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-9745-7506
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Luigi SantacroceDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-5671-8124
Grazia MarinelliDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-9163-2350
Antonio ManciniDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-7103-4086
Luigi VimercatiDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-4072-2871
Maria Elena MaggioreDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Maria Teresa D'OriaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-9376-8152
Denisa HazballaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-8160-3342
Ioana Roxana BordeaDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949
Edit XhajankaDepartment of Dental Prosthesis, Medical University of Tirana, Rruga e Dibrës, U.M.T., 1001 Tirana, Albania.ORCID 0000-0002-0843-5231
Antonio ScaranoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Marco FarronatoUOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy.ORCID 0000-0002-6209-9873
Gianluca Martino TartagliaUOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy.
Delia GiovannielloHospital A.O.S.G. Moscati, Contrada Amoretta, 83100 Avellino, Italy.ORCID 0000-0002-3327-8039
Ludovica NucciMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.
Rosario SerpicoMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0001-7330-7247
Gilberto SammartinoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-0579-794X
Loredana CapozziIstituto Zooprofilattico Sperimentale Della Puglia e Della Basilicata, 71121 Foggia, Italy.
Antonio ParisiIstituto Zooprofilattico Sperimentale Della Puglia e Della Basilicata, 71121 Foggia, Italy.ORCID 0000-0003-2744-1140
Marina Di DomenicoDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Felice LorussoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Maria ContaldoMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0002-4773-6694
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-5947-8987
University of Bari Aldo Moro · ITUniversity of Campania "Luigi Vanvitelli" · ITIstituto Zooprofilattico Sperimentale della Puglia e della Basilicata · ITUniversity of Chieti-Pescara · ITUniversity of Milan · ITAzienda Ospedaliera S.Giuseppe Moscati · ITIuliu Hațieganu University of Medicine and Pharmacy · ROUniversity of Elbasan · ALUniversity of Naples Federico II · ITUniversity of Tirana · ALUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects.

methodsa literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects.

resultsInsufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens' lungs. At present, a modulation of the dose-effect posology for children and infants is necessary.

conclusionsPregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.

Indexed as

childrencoronavirus-19pandemicspregnantSARS-CoV-2therapy

Identifiers

PMID34576859
PMCPMC8469368
OpenAlexW3199617288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.