Evidence map›Paper›PMID 34576722›Full record

ArticleMicroorganisms2021

European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe.

Heli Harvala, Kimberley S M Benschop, Natasa Berginc, Sofie Midgley, Katja Wolthers, Peter Simmonds, Susan Feeney, Jean-Luc Bailly, Audrey Mirand, Thea K Fischer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Enhancing detection of severe enterovirus infections: A data linkage study of ICD-10 codes with national enterovirus laboratory data, Denmark, 2010 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Current status of hand-foot-and-mouth disease.Journal of biomedical science · 2023
    Review
  17. Article
  18. Epidemiology of acute flaccid myelitis in children in the Netherlands, 2014 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Review
  19. Article
  20. Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 5 countries.

Heli HarvalaNHS Blood and Transplant, Microbiology Services, Colindale, London NW9 5BG, UK.
Kimberley S M BenschopNational Institute for Public Health and the Environment, 3721 MA Bilthoven, The Netherlands.
Natasa BergincLaboratory for Public Health Virology, 1000 Ljubljana, Slovenia.
Sofie MidgleyThe WHO National Reference Laboratory for Poliovirus, Statens Serum Institute, DK-2300 Copenhagen, Denmark.
Katja WolthersAmsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-1617-7049
Peter SimmondsNuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.ORCID 0000-0002-7964-4700
Susan FeeneyRegional Virus Laboratory, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK.
Jean-Luc BaillyCHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses-Associated Laboratory, 63000 Clermont-Ferrand, France.
Audrey MirandCHU Clermont-Ferrand, National Reference Centre for Enteroviruses and Parechoviruses-Associated Laboratory, 63000 Clermont-Ferrand, France.
Thea K FischerDepartment of Clinical Research, Nordsjaellands University Hospital, DK-3400 Hilleroed, Denmark.
On Behalf Of The Enpen Hospital-Based Surveillance Network
Centre Hospitalier Universitaire de Clermont-Ferrand · FRAmsterdam University Medical Centers · NLNational Institute for Public Health and the Environment · NLNational Laboratory of Health, Environment and Food · SINHS Blood and Transplant · GBRoyal Victoria Hospital · GBStatens Serum Institut · DKUniversity of Copenhagen · DKUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking.

aimsOur aim is to estimate the disease burden of EV and PeV infections in Europe via establishment of standardized surveillance for hand, foot and mouth disease (HFMD) and respiratory and neurological infections caused by these viruses. We will also assess the sensitivity of assays implemented in the network of participating laboratories so that all EV and PeV types are adequately detected. Plan. The European Non-Polio Enterovirus Network (ENPEN) has developed standardized protocols for a prospective, multi-center and cross-sectional hospital-based pilot study. Protocols include guidance for diagnosis, case definition, detection, characterization and reporting of EV and PeV infections associated with HFMD and respiratory and neurological diseases. Over 30 sites from 17 European countries have already registered to this one pilot study, likely to be commenced in 2022. BENEFITS: This surveillance will allow European-wide comparison of data on EV and PeV infection. These data will also be used to determine the burden of EV and PeV infections, which is needed to guide the further prevention measures and policies.

Indexed as

disease burdenemergingnon-polio enterovirusessurveillance

Identifiers

PMID34576722
PMCPMC8469463
OpenAlexW3196994501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.