ReviewMaterials (Basel, Switzerland)2021
Titanium Allergy Caused by Dental Implants: A Systematic Literature Review and Case Report.
Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05675241 (Characterizing the Inflammation Around Dental Implants), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity, or Both?
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Patient-reported outcomes of zirconia dental implants: a systematic review and future directions.Journal of patient-reported outcomes · 2025Pooled it
- Ultra-High-Molecular-Weight Polyethylene Cables for Sternal Closure in a Metal-Allergic Patient With Stanford Type A Acute Aortic Dissection: A Case Report.Clinical case reports · 2026Article
- Advancements in Individual Dental Implants: A State-of-the-Art Review of Materials and Technologies.Materials (Basel, Switzerland) · 2026Review
- Titanium Allergy: A Case of Foreign Body Reaction Following Laparoscopic Cholecystectomy.Cureus · 2026Article
- Titanium Dental Implant Corrosion in Peri-Implantitis and Implant Failure.Advances in experimental medicine and biology · 2026Review
- Polyetheretherketone for craniomaxillofacial defects: cases report, evaluation of patients' satisfaction and a systematic literature review.Maxillofacial plastic and reconstructive surgery · 2025Article
- The impact of physiological and parafunctional posterior occlusal forces on experimental Ti-15Zrsupracrestal dental implant - a finite element analysis.Medicine and pharmacy reports · 2025Article
- A Multicenter Study of Factors Related to Early Implant Failures-Part 2: Patient Factors.Clinical implant dentistry and related research · 2025Article
- Hypersensitivity in Orthodontics: A Systematic Review of Oral and Extra-Oral Reactions.Journal of clinical medicine · 2025Review
- Load-bearing capacity of an experimental dental implant made of Nb-1Zr.Journal of materials science. Materials in medicine · 2025Article
- Clinical Factors on Dental Implant Fractures: A Systematic Review.Dentistry journal · 2024Review
- Fracture Resistance of a Bone-Level Two-Piece Zirconia Oral Implant System-The Influence of Artificial Loading and Hydrothermal Aging.Journal of functional biomaterials · 2024Article
- How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?International journal of molecular sciences · 2023Review
- Oral Lichenoid Lesion following Dental Implant Placement and Successful Management with Free Gingival Graft: A Case Report with 10-Year Follow-Up.Medicina (Kaunas, Lithuania) · 2023Article
- Zirconium Surface Treatment via Chemical Etching.Materials (Basel, Switzerland) · 2023Article
- Which of the 37 Plates Is the Most Mechanically Appropriate for a Low-Neck Fracture of the Mandibular Condyle? A Strength Testing.Journal of clinical medicine · 2023Article
- Recent Advancements in Metallic Drug-Eluting Implants.Pharmaceutics · 2023Review
- Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone.Frontiers in bioengineering and biotechnology · 2023Article
- Effect of restoration material on marginal bone resorption around modified anatomic zirconia dental implants: A randomised controlled trial.Annals of medicine and surgery (2012) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Hypersensitivity reactions to metals may arise in predisposed patients chronically exposed to metallic materials, including dental implants made of titanium alloys. The purpose of this article was to systematically review titanium allergy manifestations in patients treated with dental implants and report a clinical case; (2) Methods: A systematic electronic search was performed for articles published in the English language until July 2021. The following eligibility criteria were adopted: (1) Population: individuals undergoing titanium and/or titanium alloy implant-supported rehabilitations; (2) Exposure: peri-implant soft tissue reactions attributable to implant insertion; (3) Outcome: evidence of titanium allergy, diagnostic methods, and forms of resolution; (3) Results: The included studies, in summary, presented evidence that titanium should not be considered an inert material, being able to trigger allergic reactions, and may be responsible for implant failure. A 55-year-old male patient received 3 implants in the posterior region of the left mandible and presented an epulis-like lesion developed from the peri-implant mucosa. The immunohistochemical analysis of the biopsy specimen confirmed the initial diagnosis of allergic reaction to titanium; (4) Conclusions: Although the evidence is weak, and titanium allergy has a low incidence, hypersensitivity reactions should not be underestimated. A rapid and conclusive diagnosis is mandatory to prevent further complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.