Evidence map›Paper›PMID 34576409›Full record

ArticleMaterials (Basel, Switzerland)2021

Therapeutic Efficacy of Artificial Skin Produced by 3D Bioprinting.

Kwang-Sik Jang, Soon-Jung Park, Jong-Jin Choi, Ha-Na Kim, Kyung-Mi Shim, Mi-Jeong Kim, Il-Ho Jang, Song-Wan Jin, Seong-Soo Kang, Se-Eun Kim and 1 more

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  10. Natural polymer-based scaffolds for soft tissue repair.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. An Overview of Extracellular Matrix-Based Bioinks for 3D Bioprinting.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kwang-Sik JangDepartment of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0001-9273-7269
Soon-Jung ParkPangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.
Jong-Jin ChoiTera Science Co., Ltd., Changwon-si 51539, Korea.
Ha-Na KimDepartment of Medicine, Konkuk University School of Medicine, Seoul 05029, Korea.
Kyung-Mi ShimDepartment of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.
Mi-Jeong KimPangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.
Il-Ho JangPangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.
Song-Wan JinPangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.
Seong-Soo KangDepartment of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.
Se-Eun KimDepartment of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.
Sung-Hwan MoonPangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.ORCID 0000-0002-6642-5699

Funding

Korea Health Industry Development Institute HI20C0184Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry 120046-2
6 · The paper itself

Abstract

The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the skin layer by using skin-derived decellularized extracellular matrix (dECM) with bioink, keratinocytes, and fibroblasts using 3D-printing technology. The therapeutic effects of the produced skin were analyzed using a chimney model that mimicked the human wound-healing process. The 3D-printed skin substitutes exhibited rapid re-epithelialization and superior tissue regeneration effects compared to the control group. These results are expected to aid the development of technologies that can provide customized skin-replacement tissues produced easily and quickly via 3D-printing technology to patients.

Indexed as

3D bioprintingartificial skinchimney wound modeldECMmouse

Identifiers

PMID34576409
PMCPMC8467964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.