ReviewInternational journal of molecular sciences2021
Selected Essential and Toxic Chemical Elements in Hypothyroidism-A Literature Review (2001-2021).
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05143918 (Assessment of Quality of Life Among Hypothyroid Patients in Assiut University Hospitals), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Quality of Life Among Hypothyroid Patients in Assiut University Hospitals
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Role of Immunological Challenges, Oxidative Stress, and Dietary Interventions in Managing Hashimoto's Thyroiditis: A Narrative Review.Nutrition reviews · 2026Review
- Assessment of essential and toxic trace element imbalances in hypothyroid patients with and without levothyroxine therapy: a case-control study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Histological and Inflammatory Changes in Thyroid Glands and Early Growth Outcomes in Offspring of Rats Exposed to Ambient Air Pollution near a Petrochemical Complex: A Preliminary Study.Life (Basel, Switzerland) · 2026Article
- Effects of Maternal Trace Elements Exposure in Early Pregnancy on Maternal Thyroid Hormones and Birth Outcomes.Biological trace element research · 2026Article
- Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Review
- Heavy metals, noradrenaline/adrenaline ratio, and microbiome-associated hormone precursor metabolites: biomarkers for social behaviour, ADHD symptoms, and executive function in children.Scientific reports · 2025Article
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- The Effect of Total Thyroidectomy on Trace Elements, Namely Zinc and Copper in Patients with Thyroid Diseases.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Preliminary investigations of plasma lipidome and selenium levels in adults with treated hypothyroidism and in healthy individuals without selenium deficiency.Scientific reports · 2024Article
- Application of Human Plasma Targeted Lipidomics and Analysis of Toxic Elements to Capture the Metabolic Complexities of Hypothyroidism.Molecules (Basel, Switzerland) · 2024Article
- Multi-element analysis of metals in human pathological and unchanged thyroid glands - pilot study.Thyroid research · 2024Article
- The Expression of Neurodegeneration-Related Genes in the Hippocampus of Hypothyroid Rats Following Long-Term Potentiation.The Eurasian journal of medicine · 2024Article
- The Relationship between Cancer Stage, Selected Immunological Parameters, Epstein-Barr Virus Infection, and Total Serum Content of Iron, Zinc, and Copper in Patients with Laryngeal Cancer.Journal of clinical medicine · 2024Article
- Genetically predicted circulating concentrations of micronutrients and risk of autoimmune thyroiditis: a Mendelian randomized study.Frontiers in immunology · 2024Article
- Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases.Frontiers in endocrinology · 2023Review
- Association of multiple blood metals with thyroid function in general adults: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3Oxidative medicine and cellular longevity · 2023Article
- Review
- Dynamic and Comparative Transcriptome Analyses Reveal Key Factors Contributing to Cadmium Tolerance in Broomcorn Millet.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormones are known for controlling metabolism of lipids, carbohydrates, proteins, minerals, and electrolytes and for regulating body temperature. Normal thyroid status depends on the chemical/elemental composition of body fluids and tissues, which changes depending on physiological state, lifestyle and environment. A deficiency or excess of certain essential chemical elements (selenium, zinc, copper, iron or fluorine) or exposure to toxic (cadmium or lead) or potentially toxic elements (manganese or chromium) interacts with thyroid hormone synthesis and may disturb thyroid homeostasis. In our review, accessible databases (Scopus, PubMed and Web of Science) were searched for articles from 2001-2021 on the influence of selected chemical elements on the development of hypothyroidism. Our review adopted some of the strengths of a systematic review. After non-eligible reports were rejected, 29 remaining articles were reviewed. The review found that disruption of the physiological levels of elements in the body adversely affects the functioning of cells and tissues, which can lead to the development of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.