Evidence map›Paper›PMID 34576301›Full record

ArticleInternational journal of molecular sciences2021

HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERα or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling.

Eddie Avellaneda, Atalie Lim, Sara Moeller, Jacqueline Marquez, Priscilla Escalante Cobb, Cristina Zambrano, Aaditya Patel, Victoria Sanchez, K Godde, Christine Broussard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Role of Estrogen Receptors in Health and Disease.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eddie AvellanedaDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.ORCID 0000-0002-8758-7646
Atalie LimDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
Sara MoellerDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
Jacqueline MarquezDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
Priscilla Escalante CobbDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
Cristina ZambranoDepartment of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Aaditya PatelDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
Victoria SanchezDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
K GoddeDepartment of Sociology/Anthropology, University of La Verne, La Verne, CA 91750, USA.ORCID 0000-0001-7888-2945
Christine BroussardDepartment of Biology, University of La Verne, La Verne, CA 91750, USA.
University of La Verne · USUniversity of California San Diego · US

Funding

Prenatal Developmental Immunotoxicity of Diethylstilbestrol and MethoxychlorR15ES017345 · NIEHS · UNIVERSITY OF LA VERNE · PI BROUSSARD, CHRISTINE ANN · 2009 to 2011
$328k
NIEHS NIH HHS ES017345-01
6 · The paper itself

Abstract

Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemicals (EDCs); suggesting that their modes of action involve interaction with or abrogation of endogenous endocrine function. This study examined whether embryonic thymocyte death and alteration of differentiation induced by the primary metabolite of methoxychlor, HPTE, rely upon estrogen receptor binding and concurrent T cell receptor signaling. Estrogen receptor inhibition of ERα or GPER did not rescue embryonic thymocyte death induced by HPTE or the model estrogen diethylstilbestrol (DES). Moreover, adverse effects induced by HPTE or DES were worsened by concurrent TCR and CD2 differentiation signaling, compared with EDC exposure post-signaling. Together, these data suggest that HPTE- and DES-induced adverse effects on embryonic thymocytes do not rely solely on ER alpha or GPER but may require both. These results also provide evidence of a potential collaborative signaling mechanism between TCR and estrogen receptors to mediate adverse effects on embryonic thymocytes, as well as highlight a window of sensitivity that modulates EDC exposure severity.

Indexed as

Cell DifferentiationAnimalsCD2 AntigensCell DeathCells, CulturedEndocrine DisruptorsEstrogen Receptor alphaFemaleMaleMiceMice, Inbred C57BLPhenolsReceptors, Antigen, T-CellReceptors, EstrogenReceptors, G-Protein-CoupledSignal Transduction2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethaneCD2 AntigensEndocrine DisruptorsEstrogen Receptor alphaGPER1 protein, mousePhenolsReceptors, Antigen, T-CellReceptors, EstrogenReceptors, G-Protein-Coupledcell deathembryonic thymocytesendocrine disrupting chemicalsestrogenic endocrine disruptorsestrogen receptor alpha (ERα)G protein-coupled estrogen receptor (GPER)HPTET cell developmentthymocyte differentiation

Identifiers

PMID34576301
PMCPMC8471014
OpenAlexW3199030890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.