Evidence map›Paper›PMID 34576291›Full record

ArticleInternational journal of molecular sciences2021

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells.

Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M Kariuki, Marcella Bassetto and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Martin SchepelmannCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-7017-5426
Nadja KupperCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Marta SladczykCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Bethan MansfieldCardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Teresa ManhardtCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Karina PiatekCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Luca IamartinoCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0003-0794-3565
Daniela RiccardiCardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Benson M KariukiSchool of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK.
Marcella BassettoDepartment of Chemistry, Faculty of Science and Engineering, Swansea University, Singleton Park Campus, Swansea SA2 8PP, UK.ORCID 0000-0002-2491-5868
Enikö KallayCenter for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-4996-0104
Medical University of Vienna · ATCardiff University · GBSwansea University · GBUniversity of Florence · IT

Funding

Austrian Science Fund P 29948-B28Austrian Science Fund P 32840-BAustrian Science Fund FWF P 29948Austrian Science Fund FWF P 32840Herzfelder'sche Familienstiftung P 32840-BHorizon 2020 675228
6 · The paper itself

Abstract

Pharmacological allosteric agonists (calcimimetics) of the extracellular calcium-sensing receptor (CaSR) have substantial gastro-intestinal side effects and induce the expression of inflammatory markers in colon cancer cells. Here, we compared the effects of both CaSR-specific (

Indexed as

Colonic NeoplasmsExtracellular SpaceGene Expression RegulationGreen Fluorescent ProteinsHEK293 CellsHT29 CellsHumansInterleukin-8Models, MolecularMolecular ConformationReceptors, Calcium-SensingStereoisomerismGreen Fluorescent ProteinsInterleukin-8Receptors, Calcium-Sensingcalcilyticcalcimimeticcalcium-sensing receptorcolon cancerenantiomerHT-29IL-8inflammationstereospecificity

Identifiers

PMID34576291
PMCPMC8464956
OpenAlexW3200088939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.