Evidence map›Paper›PMID 34576290›Full record

ArticleInternational journal of molecular sciences2021

Intermittent Hypoxia Upregulates the

Yoshinori Takeda, Asako Itaya-Hironaka, Akiyo Yamauchi, Mai Makino, Sumiyo Sakuramoto-Tsuchida, Hiroyo Ota, Ryuji Kawaguchi, Shin Takasawa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. The Impact of Intermittent Hypoxia on Metabolism and Cognition.International journal of molecular sciences · 2022
    Review
  8. Upregulation ofInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Editorial to Special Issue "Sleep Apnea and Intermittent Hypoxia 2.0".International journal of molecular sciences · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yoshinori TakedaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.ORCID 0000-0001-7738-5576
Asako Itaya-HironakaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
Akiyo YamauchiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.ORCID 0000-0001-9417-4738
Mai MakinoDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
Sumiyo Sakuramoto-TsuchidaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
Hiroyo OtaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
Ryuji KawaguchiDepartment of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Shin TakasawaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.ORCID 0000-0002-4066-0199
Nara Medical University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 08102003
6 · The paper itself

Abstract

Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), and it is a known risk factor for hypertension. The upregulation of the renin-angiotensin system has been reported in IH, and the correlation between renin and CD38 has been noted. We exposed human HEK293 and mouse As4.1 renal cells to experimental IH or normoxia for 24 h and then measured the mRNA levels using a real-time reverse transcription polymerase chain reaction. The mRNA levels of

Indexed as

ADP-ribosyl Cyclase 1AnimalsCyclic ADP-RiboseDown-RegulationHEK293 CellsHumansHypoxiaMiceMicroRNAsPromoter Regions, GeneticReninRNA, MessengerRNA, Small InterferingRyanodine Receptor Calcium Release ChannelUp-Regulation8-bromo-cyclic-ADP-riboseADP-ribosyl Cyclase 1Cyclic ADP-RiboseMicroRNAsMIRN203 microRNA, humanMIRN203 microRNA, mouseReninRNA, MessengerRNA, Small InterferingRyanodine Receptor Calcium Release ChannelCD38cyclic ADP-riboseintermittent hypoxiajuxtaglomerular cellmiR-203renin-angiotensin systemsleep apnea syndrome

Identifiers

PMID34576290
PMCPMC8466835
OpenAlexW3200284466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.