Evidence map›Paper›PMID 34576208›Full record

ArticleInternational journal of molecular sciences2021

Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line.

Melanie K Stewart, Pascal Bernard, Ching-Seng Ang, Deidre M Mattiske, Andrew J Pask

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. A novel variant in theMolecular medicine reports · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Melanie K StewartSchool of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0001-7159-4019
Pascal BernardSchool of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia.
Ching-Seng AngMelbourne Mass Spectrometry and Proteomics Facility (MMSPF), The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Deidre M MattiskeSchool of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia.
Andrew J PaskSchool of BioSciences, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0002-1900-2263
The University of Melbourne · AU

Funding

National Health and Medical Research Council APP1142481
6 · The paper itself

Abstract

Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebrates, the presence or absence of oestrogen dictates gonad differentiation, while in mammals, this mechanism has been supplanted by the testis-determining gene

Indexed as

Animalsbeta CateninCell DifferentiationEstrogensHumansMAP Kinase Kinase Kinase 1SOX9 Transcription Factorbeta CateninEstrogensMAP Kinase Kinase Kinase 1SOX9 protein, humanSOX9 Transcription Factorgonad differentiationMAP3K1oestrogenSOX9β-catenin

Identifiers

PMID34576208
PMCPMC8471392
OpenAlexW3201255720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.