Evidence map›Paper›PMID 34576197›Full record

ArticleInternational journal of molecular sciences2021

Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.

Dika A Kuljis, Kristina D Micheva, Ajit Ray, Waja Wegner, Ryan Bowman, Daniel V Madison, Katrin I Willig, Alison L Barth

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
  2. Article
  3. Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dika A KuljisCenter for the Neural Basis of Cognition, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Kristina D MichevaDepartment of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA 94304, USA.
Ajit RayCenter for the Neural Basis of Cognition, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2045-4109
Waja WegnerOptical Nanoscopy in Neuroscience, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, 37075 Göttingen, Germany.
Ryan BowmanCenter for the Neural Basis of Cognition, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Daniel V MadisonDepartment of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA 94304, USA.
Katrin I WilligOptical Nanoscopy in Neuroscience, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-1860-334X
Alison L BarthCenter for the Neural Basis of Cognition, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Center for the Neural Basis of Cognition · USStanford University · USUniversitätsmedizin Göttingen · DE

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Single synapse analysis of synaptic plasticity by combining electrophysiology and array tomographyR01MH111768 · NIMH · STANFORD UNIVERSITY · PI MADISON, VERNON DANIEL · 2017 to 2021
$2.9M
High Throughput Approaches for Cell-Specific Synapse CharacterizationRF1MH114103 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L, BRUCHEZ, MARCEL P · 2017 to 2018
$2.5M
Axonal myelination of interneurons in cortex: functional significance and plasticityR01NS094499 · NINDS · STANFORD UNIVERSITY · PI MADISON, VERNON DANIEL · 2016 to 2020
$1.7M
Deutsche Forschungsgemeinschaft EXC 171, Area A1NIH HHS 1R01NS088958-01, 1RF1MH114103-01, T32 NS086749, NS094499NIMH NIH HHS R01 MH111768NIMH NIH HHS RF1 MH114103NINDS NIH HHS R01 NS094499NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

Gephyrin has long been thought of as a master regulator for inhibitory synapses, acting as a scaffold to organize γ-aminobutyric acid type A receptors (GABA

Indexed as

AnimalsCarrier ProteinsFemaleMaleMembrane ProteinsMicroscopy, Electrochemical, ScanningNeuronsPyramidal CellsReceptors, GABA-ASynapsesCarrier ProteinsgephyrinMembrane ProteinsReceptors, GABA-Acorrelative fluorescence and electron microscopyfluorescent protein sensorsGABAA receptorsgephyrinintrabodylight microscopyoptogeneticsparvalbuminsynapsessynaptophysin

Identifiers

PMID34576197
PMCPMC8467468
OpenAlexW3201262563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.