Evidence map›Paper›PMID 34576178›Full record

ArticleInternational journal of molecular sciences2021

Impairment of the Hypothalamus-Pituitary-Thyroid Axis Caused by Naturally Occurring

Yuki Sakai, Kenji Ohba, Shigekazu Sasaki, Akio Matsushita, Hiroko Misawa Nakamura, Go Kuroda, Daisuke Tsuriya, Miho Yamashita, Takafumi Suda

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuki SakaiSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Kenji OhbaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.ORCID 0000-0001-8538-8742
Shigekazu SasakiSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Akio MatsushitaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Hiroko Misawa NakamuraSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Go KurodaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Daisuke TsuriyaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Miho YamashitaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Takafumi SudaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
Hamamatsu University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations in

Indexed as

Blotting, WesternGATA2 Transcription FactorHaploinsufficiencyHumansHypothalamusHypothyroidismMutationPituitary GlandPromoter Regions, GeneticThyroid GlandThyrotropin, beta SubunitTranscriptional ActivationGATA2 protein, humanGATA2 Transcription FactorThyrotropin, beta Subunitcentral hypothyroidismGATAhaploinsufficiencyhypothalamus–pituitary–thyroid axis (HPT axis)thyroid

Identifiers

PMID34576178
PMCPMC8467656
OpenAlexW3200774359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.