Evidence map›Paper›PMID 34576152›Full record

ArticleInternational journal of molecular sciences2021

Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation.

Han-Lin Hsu, Hong-Kai Chen, Chi-Hao Tsai, Po-Lin Liao, Yen-Ju Chan, Yu-Cheng Lee, Chen-Chen Lee, Ching-Hao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Air pollution-induced airway epithelial barrier dysfunction in COPD: a narrative review of mechanisms and therapeutic implications.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Han-Lin HsuDivision of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Hong-Kai ChenSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chi-Hao TsaiDepartment of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, NC 27517, USA.
Po-Lin LiaoInstitute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Yen-Ju ChanDepartment of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Yu-Cheng LeeGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chen-Chen LeeDepartment of Microbiology and Immunology, School of Medicine, China Medicine University, Taichung 404, Taiwan.
Ching-Hao LiDepartment of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Taipei Medical University · TWChina Medical University · TWNational Yang Ming Chiao Tung University · TWUniversity of North Carolina at Chapel Hill · USWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aryl hydrocarbon receptor (AHR) genomic pathway has been well-characterized in a number of respiratory diseases. In addition, the cytoplasmic AHR protein may act as an adaptor of E3 ubiquitin ligase. In this study, the physiological functions of AHR that regulate cell proliferation were explored using the CRISPR/Cas9 system. The doubling-time of the AHR-KO clones of A549 and BEAS-2B was observed to be prolonged. The attenuation of proliferation potential was strongly associated with either the induction of p27

Indexed as

ProteolysisSignal TransductionA549 CellsADAM17 ProteinAnimalsCell CycleCell Cycle CheckpointsCell ProliferationClone CellsEpidermal Growth FactorErbB ReceptorsHumansLungMembrane GlycoproteinsMiceMice, Inbred C57BLADAM17 ProteinEpidermal Growth FactorErbB ReceptorsLRIG1 protein, humanMembrane GlycoproteinsMitogensReceptors, Aryl Hydrocarbona disintegrin and metalloprotease 17 (ADAM17)aryl hydrocarbon receptor (AHR)cell proliferationchronic obstructive pulmonary disease (COPD)epidermal growth factor receptor (EGFR)leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1)

Identifiers

PMID34576152
PMCPMC8464816
OpenAlexW3200314093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.