Evidence map›Paper›PMID 34576147›Full record

ArticleInternational journal of molecular sciences2021

Identification of Small Molecule Inhibitors against

Amy J Rice, Russell P Pesavento, Jinhong Ren, Isoo Youn, Youngjin Kwon, Kassapa Ellepola, Chun-Tao Che, Michael E Johnson, Hyun Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Structural Analysis ofMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Amy J RiceCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Russell P PesaventoCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Jinhong RenCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Isoo YounDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-8851-0720
Youngjin KwonCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.
Kassapa EllepolaDepartment of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Chun-Tao CheDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Michael E JohnsonCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-8246-4081
Hyun LeeCenter for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-2570-8120
University of Illinois Chicago · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Multidisciplinary Oral Science TrainingT32DE018381 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COOPER, LYNDON F · 2008 to 2019
$3.6M
Antibiotic Potentiation by Targeting of a Signal Transduction SystemR33AI111760 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DAUM, ROBERT S. · 2016 to 2018
$1.5M
Antibiotic Potentiation by Targeting of a Signal Transduction SystemR21AI111760 · NIAID · UNIVERSITY OF CHICAGO · PI BOYLE-VAVRA, SUSAN, DAUM, ROBERT S. · 2014 to 2015
$448k
NIDCR NIH HHS T32 DE018381NIGMS NIH HHS P41 GM103311NIH HHS R21AI111760NIH HHS R33AI111760
6 · The paper itself

Abstract

Drug-resistant

Indexed as

High-Throughput Screening AssaysCatalytic DomainDihydroorotaseEnzyme InhibitorsMolecular Docking SimulationSmall Molecule LibrariesStaphylococcus aureusStructure-Activity RelationshipDihydroorotaseEnzyme InhibitorsSmall Molecule LibrariesantimicrobialClass I DHOasedihydroorotaseinhibitorsS. aureus

Identifiers

PMID34576147
PMCPMC8467647
OpenAlexW3199402922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.