Evidence map›Paper›PMID 34576136›Full record

ArticleInternational journal of molecular sciences2021

Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in

Mariano Schiffrin, Carine Winkler, Laure Quignodon, Aurélien Naldi, Martin Trötzmüller, Harald Köfeler, Hugues Henry, Paolo Parini, Béatrice Desvergne, Federica Gilardi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  12. PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.International journal of molecular sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariano SchiffrinCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.
Carine WinklerCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.
Laure QuignodonCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.
Aurélien NaldiCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.
Martin TrötzmüllerCore Facility Mass Spectrometry, Medical University of Graz, 8036 Graz, Austria.
Harald KöfelerCore Facility Mass Spectrometry, Medical University of Graz, 8036 Graz, Austria.
Hugues HenryCentre Hospitalier Universitaire Vaudois (CHUV), Lausanne Faculty of Biology and Medicine, CH-1011 Lausanne, Switzerland.
Paolo PariniCardioMetabolic Unit, Department of Medicine and Department of Laboratory Medicine, Karolinska Insititutet and Theme Inflammation and Ageing Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Béatrice DesvergneCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.
Federica GilardiCenter of Integrative Genomics, Genopode, Lausanne Faculty of Biology and Medicine, CH-1015 Lausanne, Switzerland.

Funding

Etat de Vaud NASchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_1564771Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_135583Université de Lausanne 8466
6 · The paper itself

Abstract

Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, histological and lipidomic analyses to systematically compare male and female liver steatosis. We characterized hepatosteatosis in three independent mouse models of NAFLD,

Indexed as

Sex CharacteristicsAnimalsDisease Models, AnimalFatty AcidsFemaleGene Expression RegulationGonadal Steroid HormonesInflammationLipid DropletsLiverMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseasePhenotypeFatty AcidsGonadal Steroid HormonesPPAR gammaTriglycerideshepatic sex-biased gene expressionlipidomicsnonalcoholic fatty liver disease (NAFLD)sex dimorphism

Identifiers

PMID34576136
PMCPMC8467431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.