Evidence map›Paper›PMID 34576135›Full record

ReviewInternational journal of molecular sciences2021

Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum.

Emilia Przygrodzka, Michele R Plewes, John S Davis

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

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  12. The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy.International journal of molecular sciences · 2025
    Article
  13. Fundamental research · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emilia PrzygrodzkaOlson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-3255, USA.
Michele R PlewesOlson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-3255, USA.
John S DavisOlson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198-3255, USA.
University of Nebraska Medical Center · US

Funding

The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI GEORGE R BOUSFIELD · 2009 to 2026
$25.9M
Metabolic Regulators of Corpus Luteum FunctionR01HD092263 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2021
$1.6M
Metabolic Events Controlling Ovarian SteroidogenesisR01HD087402 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2019
$425k
Signals controlling tissues homeostasis in the ovaryI01BX004272 · VA · OMAHA VA MEDICAL CENTER · PI DAVIS, JOHN S · 2020 to 2023
–
Mitochondrial Dynamics and SteroidogenesisIK2BX004911 · VA · OMAHA VA MEDICAL CENTER · PI Michele R Plewes · 2021 to 2026
–
Agricultural Research Service 2017-67015-26450Agricultural Research Service 2018-08068BLRD VA I01 BX000512BLRD VA I01 BX004272BLRD VA IK2 BX004911BLRD VA IK6 BX005797Eunice Kennedy Shriver National Institute of Child Health and Human Development HD087402Eunice Kennedy Shriver National Institute of Child Health and Human Development HD092263NIA NIH HHS P01 AG029531NICHD NIH HHS R01 HD087402NICHD NIH HHS R01 HD092263U.S. Department of Veterans Affairs BX004911
6 · The paper itself

Abstract

The corpus luteum is an endocrine gland that synthesizes the steroid hormone progesterone. luteinizing hormone (LH) is a key luteotropic hormone that stimulates ovulation, luteal development, progesterone biosynthesis, and maintenance of the corpus luteum. Luteotropic and luteolytic factors precisely regulate luteal structure and function; yet, despite recent scientific progress within the past few years, the exact mechanisms remain largely unknown. In the present review, we summarize the recent progress towards understanding cellular changes induced by LH in steroidogenic luteal cells. Herein, we will focus on the effects of LH on inter-organelle communication and steroid biosynthesis, and how LH regulates key protein kinases (i.e., AMPK and MTOR) responsible for controlling steroidogenesis and autophagy in luteal cells.

Indexed as

AnimalsAutophagyCorpus LuteumFemaleHumansLuteal CellsLuteinizing HormoneOrganellesSignal TransductionLuteinizing Hormoneautophagycholesterolcorpus luteumLHlipid dropletsmitochondriaprogesterone

Identifiers

PMID34576135
PMCPMC8470545
OpenAlexW3200794610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.