Evidence map›Paper›PMID 34576134›Full record

ReviewInternational journal of molecular sciences2021

Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization.

Matteo Ferro, Ottavio de Cobelli, Mihai Dorin Vartolomei, Giuseppe Lucarelli, Felice Crocetto, Biagio Barone, Alessandro Sciarra, Francesco Del Giudice, Matteo Muto, Martina Maggi and 7 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. AnCurrent radiopharmaceuticals · 2024
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  18. Using active surveillance for Gleason 7 (3+4) prostate cancer: A narrative review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
    Review
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  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matteo FerroDepartment of Urology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-9250-7858
Ottavio de CobelliDepartment of Urology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Mihai Dorin VartolomeiDepartment of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology from Târgu Mureș, 540142 Târgu Mureș, Romania.
Giuseppe LucarelliUrology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-7807-1229
Felice CrocettoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-4315-7660
Biagio BaroneDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-4884-132X
Alessandro SciarraDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.
Francesco Del GiudiceDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3865-5988
Matteo MutoDepartment of Onco-Hematological Diseases, U.O.C. Radiotherapy-Azienda Ospedaliera San Giuseppe Moscati-(AV), 83100 Avellino, Italy.
Martina MaggiDepartment of Maternal Infant and Urologic Sciences, Policlinico Umberto I Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-4672-850X
Giuseppe CarrieriDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.
Gian Maria BusettoDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-7291-0316
Ugo FalagarioDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.
Daniela TerraccianoDepartment of Translational Medical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-4296-429X
Luigi CormioDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, Italy.
Gennaro MusiDepartment of Urology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Octavian Sabin TataruThe Institution Organizing University Doctoral Studies (I.O.S.U.D.), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology from Târgu Mureș, 540142 Târgu Mureș, Romania.ORCID 0000-0001-7057-7815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiomics and genomics represent two of the most promising fields of cancer research, designed to improve the risk stratification and disease management of patients with prostate cancer (PCa). Radiomics involves a conversion of imaging derivate quantitative features using manual or automated algorithms, enhancing existing data through mathematical analysis. This could increase the clinical value in PCa management. To extract features from imaging methods such as magnetic resonance imaging (MRI), the empiric nature of the analysis using machine learning and artificial intelligence could help make the best clinical decisions. Genomics information can be explained or decoded by radiomics. The development of methodologies can create more-efficient predictive models and can better characterize the molecular features of PCa. Additionally, the identification of new imaging biomarkers can overcome the known heterogeneity of PCa, by non-invasive radiological assessment of the whole specific organ. In the future, the validation of recent findings, in large, randomized cohorts of PCa patients, can establish the role of radiogenomics. Briefly, we aimed to review the current literature of highly quantitative and qualitative results from well-designed studies for the diagnoses, treatment, and follow-up of prostate cancer, based on radiomics, genomics and radiogenomics research.

Indexed as

Diagnostic ImagingGenomicsHumansMaleMolecular ImagingProstatic NeoplasmsRisk Factorsgenomicsmolecular characterizationMRIPET-CTprostate cancerradiogenomicsradiomics

Identifiers

PMID34576134
PMCPMC8465891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.