Evidence map›Paper›PMID 34576132›Full record

ArticleInternational journal of molecular sciences2021

Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation.

Jochen Rutz, Aicha Benchellal, Wajdi Kassabra, Sebastian Maxeiner, August Bernd, Stefan Kippenberger, Nadja Zöller, Felix K-H Chun, Eva Juengel, Roman A Blaheta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Effect ofJournal of thoracic disease · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Effects of Curcumin and Lactoferrin to Inhibit the Growth and Migration of Prostatic Cancer Cells.International journal of environmental research and public health · 2022
    Article
  13. Review
  14. Curcumin 3.0-Therapeutic and Diagnostic Potential in Cancer and Beyond.International journal of molecular sciences · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jochen RutzDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Aicha BenchellalDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Wajdi KassabraDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Sebastian MaxeinerDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
August BerndDepartment of Dermatology, Venereology, and Allergology, Goethe-University, 60590 Frankfurt am Main, Germany.
Stefan KippenbergerDepartment of Dermatology, Venereology, and Allergology, Goethe-University, 60590 Frankfurt am Main, Germany.
Nadja ZöllerDepartment of Dermatology, Venereology, and Allergology, Goethe-University, 60590 Frankfurt am Main, Germany.
Felix K-H ChunDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Eva JuengelDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Roman A BlahetaDepartment of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-0129-7972
Goethe University Frankfurt · DE

Funding

Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany N/A
6 · The paper itself

Abstract

Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1-0.4 µg/mL) and subsequently irradiated with 1.65 J/cm

Indexed as

LightApoptosisCell AdhesionCell CycleCell Line, TumorCell MovementCell ProliferationClone CellsCurcuminHumansHuman Umbilical Vein Endothelial CellsIntegrinsMaleNeoplasm MetastasisProstatic NeoplasmsCurcuminIntegrinscurcumingrowthlight irradiationmetastasisproliferationprostate cancer

Identifiers

PMID34576132
PMCPMC8469895
OpenAlexW3201647914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.