Evidence map›Paper›PMID 34576130›Full record

ArticleInternational journal of molecular sciences2021

Beneficial Effects of Tamarind Trypsin Inhibitor in Chitosan-Whey Protein Nanoparticles on Hepatic Injury Induced High Glycemic Index Diet: A Preclinical Study.

Ana J F C Aguiar, Jaluza L C de Queiroz, Pedro P A Santos, Christina S Camillo, Alexandre C Serquiz, Izael S Costa, Gerciane S Oliveira, Ana F T Gomes, Lídia L R Matias, Rafael O A Costa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Encapsulated Peptides and Proteins with an Effect on Satiety.Nanomaterials (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ana J F C AguiarBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Jaluza L C de QueirozBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Pedro P A SantosStructural and Functional Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Christina S CamilloStructural and Functional Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Alexandre C SerquizNutrition Course, University Center of Rio Grande do Norte, Natal 59.014-545, RN, Brazil.
Izael S CostaBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Gerciane S OliveiraNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Ana F T GomesNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Lídia L R MatiasBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Rafael O A CostaBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.
Thaís S PassosDepartment of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.ORCID 0000-0003-2054-1544
Ana H A MoraisBiochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59.078-970, RN, Brazil.ORCID 0000-0002-6460-911X
Universidade Federal do Rio Grande do Norte · BRCentro Universitário do Rio Grande do Norte · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 426116/2018-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

Several studies have sought new therapies for obesity and liver diseases. This study investigated the effect of the trypsin inhibitor isolated from tamarind seeds (TTI), nanoencapsulated in chitosan and whey protein isolate (ECW), on the liver health status of the Wistar rats fed with a high glycemic index (HGLI) diet. The nanoformulations without TTI (CW) and ECW were obtained by nanoprecipitation technique, physically and chemically characterized, and then administered to the animals. The adult male Wistar rats (

Indexed as

DietGlycemic IndexAnimalsBlood GlucoseChitosanFastingHomeostasisInsulinInsulin ResistanceKidneyLiverMaleNanoparticlesRatsRats, WistarReference ValuesBlood GlucoseChitosanInsulinTrypsin InhibitorsWhey Proteinshyperglycemiananoencapsulationprotease inhibitor

Identifiers

PMID34576130
PMCPMC8470918
OpenAlexW3199751055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.