Evidence map›Paper›PMID 34576089›Full record

ArticleInternational journal of molecular sciences2021

Uridine Treatment of the First Known Case of SLC25A36 Deficiency.

Luisa Jasper, Pasquale Scarcia, Stephan Rust, Janine Reunert, Ferdinando Palmieri, Thorsten Marquardt

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. The Role of Uridine in Health and Disease.Journal of inflammation research · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Luisa JasperDepartment of Pediatrics, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A13, 48149 Münster, Germany.
Pasquale ScarciaDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy.ORCID 0000-0001-6216-0411
Stephan RustDepartment of Pediatrics, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A13, 48149 Münster, Germany.
Janine ReunertDepartment of Pediatrics, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A13, 48149 Münster, Germany.
Ferdinando PalmieriDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy.
Thorsten MarquardtDepartment of Pediatrics, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A13, 48149 Münster, Germany.
University Hospital Münster · DEUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SLC25A36 is a pyrimidine nucleotide carrier playing an important role in maintaining mitochondrial biogenesis. Deficiencies in SLC25A36 in mouse embryonic stem cells have been associated with mtDNA depletion as well as mitochondrial dysfunction. In human beings, diseases triggered by

Indexed as

ChildChild, PreschoolFemaleGrowth and DevelopmentHumansInfantInfant, NewbornMitochondrial Membrane Transport ProteinsMutant ProteinsProtein TransportThyrotropinUridineMitochondrial Membrane Transport ProteinsMutant ProteinsSLC25A36 protein, humanThyrotropinUridinebypass therapymitochondrial solute carrierpyrimidine nucleotide carrierSLC25A33SLC25A36uridine

Identifiers

PMID34576089
PMCPMC8470663
OpenAlexW3201114419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.