Evidence map›Paper›PMID 34576031›Full record

ArticleInternational journal of molecular sciences2021

Alternative Splicing Regulation of Low-Frequency Genetic Variants in Exon 2 of

Seonggyun Han, Yirang Na, Insong Koh, Kwangsik Nho, Younghee Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Increased circulating TREM2Brain, behavior, & immunity - health · 2026
    Article
  2. Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025
    Review
  3. LncRNANon-coding RNA research · 2025
    Article
  4. Review
  5. [Tau Protein Induces Aberrant Alternative Splicing Changes in PS19 Transgenic Mice].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Article
  6. Article
  7. Article
  8. Profile ofInternational journal of molecular sciences · 2022
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Seonggyun HanDepartment of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Yirang NaTransdisciplinary Department of Medicine and Advanced Technology, Seoul National University Hospital, Seoul 03080, Korea.
Insong KohDepartment of Physiology, Hanyang University, Seoul 04763, Korea.ORCID 0000-0001-6896-9748
Kwangsik NhoDepartment of Radiology and Imaging Sciences, Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Younghee LeeDepartment of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.ORCID 0000-0002-6850-0082
University of Utah · USHanyang University · KRIndiana University School of MedicineSeoul National University Hospital · KR

Funding

Integrative analysis of alternative splicing in Alzheimer's diseaseR03AG063250 · NIA · UNIVERSITY OF UTAH · PI LEE, YOUNGHEE · 2019 to 2020
$323k
Ministry of Science and ICT, South Korea IITP-2018-2018-0-01833National Research Foundation of Korea 2017M3C9A6047623National Research Foundation of Korea 2020R1F1A106888711NIA NIH HHS AG063250
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Predisposition to DiseaseAgedAlternative SplicingAlzheimer DiseaseBrainExonsFemaleGene FrequencyGenetic VariationHumansMaleMembrane GlycoproteinsReceptors, ImmunologicRegulatory Sequences, Nucleic AcidRNA-SeqRNA SplicingMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanaggregation of low-frequency variantsalternative splicingAlzheimer’s diseaselow-frequency variantTREM2

Identifiers

PMID34576031
PMCPMC8471326
OpenAlexW3200283473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.