Evidence map›Paper›PMID 34576010›Full record

ReviewInternational journal of molecular sciences2021

A Journey on the Skin Microbiome: Pitfalls and Opportunities.

Dario Pistone, Gabriele Meroni, Simona Panelli, Enza D'Auria, Miriam Acunzo, Ajay Ratan Pasala, Gian Vincenzo Zuccotti, Claudio Bandi, Lorenzo Drago

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Seed Oil ofInternational journal of molecular sciences · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
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  11. Review
  12. The Impact of Athymic Nude Mouse Stock and Colony Source on the Severity of Corynebacterium-Associated Hyperkeratosis.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Microbe Interactions within the Skin Microbiome.Antibiotics (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dario PistonePediatric Clinical Research Center "Invernizzi", Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157 Milan, Italy.ORCID 0000-0002-1703-7470
Gabriele MeroniDepartment of Biomedical Surgical and Dental Sciences-One Health Unit, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-2772-6410
Simona PanelliPediatric Clinical Research Center "Invernizzi", Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157 Milan, Italy.ORCID 0000-0001-6083-8786
Enza D'AuriaDepartment of Pediatrics, Children's Hospital Vittore Buzzi, University of Milan, 20154 Milan, Italy.ORCID 0000-0003-2750-5810
Miriam AcunzoDepartment of Pediatrics, Children's Hospital Vittore Buzzi, University of Milan, 20154 Milan, Italy.
Ajay Ratan PasalaPediatric Clinical Research Center "Invernizzi", Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157 Milan, Italy.
Gian Vincenzo ZuccottiPediatric Clinical Research Center "Invernizzi", Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2795-9874
Claudio BandiPediatric Clinical Research Center "Invernizzi", Department of Biosciences, University of Milan, 20133 Milan, Italy.
Lorenzo DragoDepartment of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5206-540X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human skin microbiota is essential for maintaining homeostasis and ensuring barrier functions. Over the years, the characterization of its composition and taxonomic diversity has reached outstanding goals, with more than 10 million bacterial genes collected and cataloged. Nevertheless, the study of the skin microbiota presents specific challenges that need to be addressed in study design. Benchmarking procedures and reproducible and robust analysis workflows for increasing comparability among studies are required. For various reasons and because of specific technical problems, these issues have been investigated in gut microbiota studies, but they have been largely overlooked for skin microbiota. After a short description of the skin microbiota, the review tackles methodological aspects and their pitfalls, covering NGS approaches and high throughput culture-based techniques. Recent insights into the "core" and "transient" types of skin microbiota and how the manipulation of these communities can prevent or combat skin diseases are also covered. Finally, this review includes an overview of the main dermatological diseases, the changes in the microbiota composition associated with them, and the recommended skin sampling procedures. The last section focuses on topical and oral probiotics to improve and maintain skin health, considering their possible applications for skin diseases.

Indexed as

MicrobiotaDysbiosisHumansMetagenomicsProbioticsSkinSkin DiseasesculturomicsNGSskin microbiotaskin sampling techniques

Identifiers

PMID34576010
PMCPMC8469928

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.