Evidence map›Paper›PMID 34576009›Full record

ArticleInternational journal of molecular sciences2021

Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development.

Mingjie Zheng, Shannon Erhardt, Di Ai, Jun Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Transcriptional Regulation of Cardiac Development and Disease.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mingjie ZhengDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0003-0735-3995
Shannon ErhardtDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Di AiDepartment of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-2972-4582
Jun WangDepartment of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0001-6874-9331
The University of Texas MD Anderson Cancer Center · USEmory University · USThe University of Texas Health Science Center at Houston · US

Funding

Genetic dissection of Cardiac Conduction System homeostasis and RepairR01HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jun Wang · 2020 to 2026
$3.0M
Genetic dissection of Cardiac Conduction System homeostasis and regenerationR56HL142704 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WANG, JUN · 2018 to 2018
$396k
NHLBI NIH HHS R01 HL142704NHLBI NIH HHS R56 HL142704NIH HHS R01HL142704
6 · The paper itself

Abstract

The bone morphogenetic protein (Bmp) signaling pathway and the basic helix-loop-helix (bHLH) transcription factor Hand1 are known key regulators of cardiac development. In this study, we investigated the Bmp signaling regulation of

Indexed as

OrganogenesisSignal TransductionAnimalsBasic Helix-Loop-Helix ProteinsBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Embryo, MammalianHeartMiceMice, KnockoutBasic Helix-Loop-Helix ProteinsBmp2 protein, mouseBmp4 protein, mouseBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Hand1 protein, mouseBmp signalingcardiomyocyte differentiationHand1heart developmentSmadtranscriptional regulation

Identifiers

PMID34576009
PMCPMC8465227
OpenAlexW3199744117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.