Evidence map›Paper›PMID 34575994›Full record

ArticleInternational journal of molecular sciences2021

Topical Neck Cooling Prolongs Survival of Rats with Intra-Abdominal Feculent Sepsis by Activation of the Vagus Nerve.

Aimee Y Zhang, Katherine M Marsh, Radhika Rastogi, Di Wu, Eric J Charles, Irving L Kron, Robert G Sawyer, Zequan Yang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aimee Y ZhangDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.ORCID 0000-0002-3660-3917
Katherine M MarshDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Radhika RastogiDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.ORCID 0000-0002-9859-9917
Di WuDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Eric J CharlesDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Irving L KronDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
Robert G SawyerDepartment of Surgery, Western Michigan University Medical School, Kalamazoo, MI 49008, USA.ORCID 0000-0002-8155-2661
Zequan YangDepartment of Surgery, University of Virginia Health System, Charlottesville, VA 22903, USA.
University of Virginia Health System · USWestern Michigan University · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
The splenic CD4+ T cells mediate myocardial ischemia-reperfusion injuryR01HL130082 · NHLBI · UNIVERSITY OF VIRGINIA · PI YANG, ZEQUAN · 2016 to 2019
$1.6M
Surgical Infectious Diseses and Transplantation Training GrantT32AI078875 · NIAID · UNIVERSITY OF VIRGINIA · PI SAWYER, ROBERT G · 2009 to 2013
$947k
Commonwealth Health Research Board 207-12-21NHLBI NIH HHS R01HL130082NHLBI NIH HHS T32 HL007849NIH HHS T32AI078875NIH HHS T32HL007849NIH HHS T32HL007849-21A1University of Virginia George A. Beller, M.D. Research Award n/a
6 · The paper itself

Abstract

Global hypothermia prolongs survival in rats with intraabdominal feculent sepsis by inhibiting inflammatory responses. We hypothesized that topical neck cooling (TNC) has similar benefits. Septic shock was induced by cecal ligation and incision (CLI) in Sprague Dawley rats. Rats were randomized to sham laparotomy, control with CLI, CLI with TNC, or vagotomy at the gastroesophageal junction before CLI and TNC. Two more groups underwent peritoneal washout with and without TNC two hours after CLI. TNC significantly lowered neck skin temperature (16.7 ± 1.4 vs. 30.5 ± 0.6 °C,

Indexed as

Hyperthermia, InducedShock, SepticVagus NerveAnimalsCytokinesRatsRats, Sprague-DawleyCytokinesinflammatory responseintraabdominal sepsisneck coolingshocktopical hypothermiavagus nerve

Identifiers

PMID34575994
PMCPMC8465551
OpenAlexW3199553214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.