Evidence map›Paper›PMID 34575978›Full record

ArticleInternational journal of molecular sciences2021

A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.

Ju Hye Jang, Hyun Kim, In Young Jung, Ju Hyun Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. 1,25-Dihydroxy vitamin DAnnals of medicine · 2025
    Article
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ju Hye JangResearch Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Korea.
Hyun KimResearch Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Korea.
In Young JungDivision of Applied Life Science (BK21Four), Gyeongsang National University, Jinju 52828, Korea.
Ju Hyun ChoResearch Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Korea.
Gyeongsang National University · KR

Funding

National Research Foundation of Korea 2020R1C1C1006149National Research Foundation of Korea 2020R1I1A3051795
6 · The paper itself

Abstract

The ubiquitin-editing enzyme A20 is known to inhibit the NF-κB transcription factor in the Toll-like receptor (TLR) pathways, thereby negatively regulating inflammation. However, its role in the TLR signaling pathway in fish is still largely unknown. Here, we identified a gene encoding A20 (OmA20) in rainbow trout,

Indexed as

AnimalsGene Expression RegulationInflammationLipopolysaccharidesNF-kappa BOncorhynchus mykissPolyubiquitinProtein DomainsSignal TransductionTNF Receptor-Associated Factor 6Tumor Necrosis Factor alpha-Induced Protein 3UbiquitinationLipopolysaccharidesNF-kappa BPolyubiquitinTNF Receptor-Associated Factor 6Tumor Necrosis Factor alpha-Induced Protein 3A20 (TNFAIP3)deubiquitinase (DUB)rainbow troutRTH-149TRAF6

Identifiers

PMID34575978
PMCPMC8472768
OpenAlexW3200891610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.