Evidence map›Paper›PMID 34575952›Full record

ArticleInternational journal of molecular sciences2021

Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H

Giorgia Pellavio, Giacomo Rossino, Giulia Gastaldi, Daniela Rossi, Pasquale Linciano, Simona Collina, Umberto Laforenza

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Neurodegeneration: can metabolites fromFrontiers in pharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giorgia PellavioDepartment of Molecular Medicine, Human Physiology Unit, University of Pavia, I-27100 Pavia, Italy.
Giacomo RossinoDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, I-27100 Pavia, Italy.
Giulia GastaldiDepartment of Molecular Medicine, Human Physiology Unit, University of Pavia, I-27100 Pavia, Italy.
Daniela RossiDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, I-27100 Pavia, Italy.ORCID 0000-0002-2458-3728
Pasquale LincianoDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, I-27100 Pavia, Italy.ORCID 0000-0003-0382-7479
Simona CollinaDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, I-27100 Pavia, Italy.ORCID 0000-0002-2954-7558
Umberto LaforenzaDepartment of Molecular Medicine, Human Physiology Unit, University of Pavia, I-27100 Pavia, Italy.ORCID 0000-0003-2951-5983
University of Pavia · IT

Funding

Department of Molecular Medicine of the University of Pavia Dipartimenti di Eccellenza (2018-2022)
6 · The paper itself

Abstract

Sigma1 Receptor (S1R) is involved in oxidative stress, since its activation is triggered by oxidative or endoplasmic reticulum stress. Since specific aquaporins (AQP), called peroxiporins, play a relevant role in controlling H

Indexed as

AquaporinsEndoplasmic Reticulum StressHeLa CellsHumansHydrogen PeroxideOxidative StressPermeabilityPeroxiredoxinsReactive Oxygen SpeciesReceptors, sigmaSigma-1 ReceptorAquaporinsHydrogen PeroxidePeroxiredoxinsReactive Oxygen SpeciesReceptors, sigmaSigma-1 Receptorhydrogen peroxideneurodegenerative diseasesoxidative stressperoxiporinsSigma1 receptor modulatorsSigma1 receptorswater channels

Identifiers

PMID34575952
PMCPMC8467392
OpenAlexW3200894392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.