Evidence map›Paper›PMID 34575942›Full record

ArticleInternational journal of molecular sciences2021

Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer.

Nokuphila Winifred Nompumelelo Simelane, Cherie Ann Kruger, Heidi Abrahamse

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Cytotoxic Effects of Combinative ZnPcSInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nokuphila Winifred Nompumelelo SimelaneLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South Africa.ORCID 0000-0003-3368-7147
Cherie Ann KrugerLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South Africa.ORCID 0000-0002-4556-9132
Heidi AbrahamseLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South Africa.ORCID 0000-0001-5002-827X
University of Johannesburg · ZA

Funding

Cancer Association of South Africa (CANSA) Research Funding Grant xxxxNational Research Foundation Thuthuka Fund TTK180409318735South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa 98337
6 · The paper itself

Abstract

Colorectal cancer (CRC) is an aggressive cancer that remains a challenge to diagnose and treat. Photodynamic diagnosis (PDD) and therapy (PDT) are novel alternative techniques, which can enhance early diagnosis, as well as elicit tumor cell death. This is accomplished through photosensitizer (PS) mediated fluorescence and cytotoxic reactive oxygen species activation upon laser light irradiation excitation at specific low and high range wavelengths, respectively. However, the lack of PS target tumor tissue specificity often hampers these techniques. This study successfully fabricated a bioactive nanoconjugate, ZnPcS

Indexed as

ImmunotherapyAntineoplastic AgentsCell Line, TumorCell ProliferationColorectal NeoplasmsGoldHumansImmunoconjugatesIndolesMetal NanoparticlesOrganometallic CompoundsPhotochemotherapyReactive Oxygen SpeciesAntineoplastic AgentsGoldImmunoconjugatesIndolesOrganometallic CompoundsReactive Oxygen Specieszinc(II) phthalocyanine trisulfonic acidcolorectal cancernanoparticlephotodynamic diagnosisphotodynamic therapytumor targetingzinc phthalocyanine

Identifiers

PMID34575942
PMCPMC8466279
OpenAlexW3200688600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.