ArticleInternational journal of molecular sciences2021
Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Fraction-Seq: An Integrated Experimental and Computational Workflow for Determining the Localization and Abundance of Small Non-Coding RNAs in Subcellular Compartments.Non-coding RNA · 2026Article
- SmithRNAs: A Common Feature among Metazoa.Genome biology and evolution · 2025Article
- The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting.Journal of virology · 2024Article
- RNA Regulatory Networks 2.0.International journal of molecular sciences · 2023Article
- A tRNA-derived fragment present in E. coli OMVs regulates host cell gene expression and proliferation.PLoS pathogens · 2022Article
- An Expanded Landscape of Unusually Short RNAs in 11 Samples from Six Eukaryotic Organisms.Non-coding RNA · 2022Article
- TheFrontiers in molecular biosciences · 2022Review
- RNA Sequencing Unveils Very Small RNAs With Potential Regulatory Functions in Bacteria.Frontiers in molecular biosciences · 2022Article
- A New Specific and Sensitive RT-qPCR Method Based on Splinted 5' Ligation for the Quantitative Detection of RNA Species Shorter than microRNAs.Non-coding RNA · 2021Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Using a modified RNA-sequencing (RNA-seq) approach, we discovered a new family of unusually short RNAs mapping to ribosomal RNA 5.8S, which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members contain. Using a new quantitative detection method that we developed, we confirmed our RNA-seq data and determined that the minimal core doRNA sequence and its 13-nt variant C-doRNA (doRNA with a 5' Cytosine) are the two most abundant doRNAs, which, together, may outnumber microRNAs. The C-doRNA/doRNA ratio is stable within species but differed between species. doRNA and C-doRNA are mainly cytoplasmic and interact with heterogeneous nuclear ribonucleoproteins (hnRNP) A0, A1 and A2B1, but not Argonaute 2. Reporter gene activity assays suggest that C-doRNA may function as a regulator of Annexin II receptor (AXIIR) expression. doRNAs are differentially expressed in prostate cancer cells/tissues and may control cell migration. These findings suggest that unusually short RNAs may be more abundant and important than previously thought.
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Registered trials
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