Evidence map›Paper›PMID 34575894›Full record

ArticleInternational journal of molecular sciences2021

Novel Coumarin-Thiadiazole Hybrids and Their Cu(II) and Zn(II) Complexes as Potential Antimicrobial Agents and Acetylcholinesterase Inhibitors.

Dariusz Karcz, Karolina Starzak, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta, Daniel Kamiński, Bernadette Creaven, Hollie Jenkins, Piotr Radomski, Anna Miłoś, Lidia Ślusarczyk and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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  3. Advanced Research on Biological Properties-A Study on the Activity of theInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Dariusz KarczDepartment of Chemical Technology and Environmental Analytics (C1), Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland.ORCID 0000-0002-9848-2508
Karolina StarzakDepartment of Chemical Technology and Environmental Analytics (C1), Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland.ORCID 0000-0002-0343-5363
Ewa CiszkowiczDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszów, Poland.ORCID 0000-0003-3401-2264
Katarzyna Lecka-SzlachtaDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszów, Poland.
Daniel KamińskiDepartment of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Maria Curie-Sklodowska University in Lublin, 20-031 Lublin, Poland.
Bernadette CreavenSchool of Chemical and Pharmaceutical Sciences, Technological University Dublin, Central Quad, D07 ADY7 Grangegorman, Ireland.
Hollie JenkinsDepartment of Applied Science, Technological University Dublin, D24 FKT9 Tallaght, Ireland.
Piotr RadomskiDepartment of Chemical Technology and Environmental Analytics (C1), Faculty of Chemical Engineering and Technology, Cracow University of Technology, 31-155 Kraków, Poland.
Anna MiłośDepartment of Biotechnology and Bioinformatics, Faculty of Chemistry, Doctoral School of Engineering and Technical Sciences at the Rzeszow University of Technology, 35-959 Rzeszow, Poland.
Lidia ŚlusarczykDepartment of Biophysics, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID 0000-0002-8098-7540
Arkadiusz MatwijczukDepartment of Biophysics, University of Life Sciences in Lublin, 20-950 Lublin, Poland.ORCID 0000-0003-2630-120X
Cracow University of Technology · PLRzeszów University of Technology · PLTechnological University Dublin · IEUniversity of Life Sciences in Lublin · PLMaria Curie-Skłodowska University · PL

Funding

Narodowym Centrum Nauki 2019/35/B/NZ7/02756
6 · The paper itself

Abstract

A series of coumarin-thiadiazole hybrids and their corresponding Cu(II) and Zn(II) complexes were synthesized and characterized with the use of spectroscopic techniques. The results obtained indicate that all the coumarin-thiadiazole hybrids act as bidentate chelators of Cu(II) and Zn(II) ions. The complexes isolated differ in their ligand:metal ratio depending on the central metal. In most cases, the Zn(II) complexes are characteristic of a 1:1 ligand:metal ratio, while in the Cu(II) complexes the ligand:metal ratio is 2:1. All compounds were tested as potential antibacterial agents against Gram-positive (

Indexed as

AcetylcholinesteraseAnti-Bacterial AgentsAnti-Infective AgentsCholinesterase InhibitorsCopperCoumarinsCrystallography, X-RayEscherichia coliLigandsMagnetic Resonance SpectroscopyMetalsMicrobial Sensitivity TestsNeurodegenerative DiseasesPseudomonas aeruginosaSchiff BasesSpectrometry, FluorescenceAcetylcholinesteraseAnti-Bacterial AgentsAnti-Infective AgentsCholinesterase InhibitorsCoppercoumarinCoumarinsLigandsMetalsSchiff BasesThiadiazolesThiazolesZincacetylcholinesterase inhibitorsantibacterial activityantimicrobialcomplexescoumarinhybridsneurodegenerationthiadiazole

Identifiers

PMID34575894
PMCPMC8471537
OpenAlexW3197674462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.