ReviewInternational journal of molecular sciences2021
Sarcopenia: Etiology, Nutritional Approaches, and miRNAs.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05772910 (Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.), which is not on this map. Cited by 97 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.
Who cites it
97 citing papers in PubMed, 7 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Effectiveness of Whey Protein Supplementation in Weight Loss Interventions for Patients with Obesity: A Systematic Review.Nutrients · 2026Pooled it
- Sarcopenia as a prognostic marker in patients undergoing pancreaticoduodenectomy: an updated meta-analysis.Frontiers in oncology · 2025Pooled it
- The effectiveness of unsupervised home-based exercise for improving lower extremity physical function in older adults in Western and Eastern cultures: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.PloS one · 2024Pooled it
- Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Sarcopenia as a risk factor of progression-free survival in patients with metastases: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Exercise training to preserve vitality capacity in ageing.Experimental physiology · 2026Review
- Review
- Observational
- Preventive Effect ofNutrients · 2026Article
- Article
- Creatine increases muscle fiber size in embryonic chick muscle cells and age-dependent swimming performance in zebrafish.Scientific reports · 2026Article
- Investigation of myofiber composition changes and molecular mechanisms in rabbit meat quality development during growth.BMC genomics · 2026Article
- Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair.Neurochemical research · 2026Review
- Effects of progressive multimodal resistance training with varied muscle actions and range of motion on bone mineral density in osteopenic older women: a pilot study.Frontiers in physiology · 2026Article
- Integrated bioinformatics and mendelian randomization reveal a six-gene diagnostic signature and key role of CYP26B1 in sarcopenia.Frontiers in molecular biosciences · 2026Article
- Muscle strength and the risk of Multimorbidity in Middle-aged and older Chinese adults: A prospective cohort study.Aging clinical and experimental research · 2025Article
- Psoas muscle CT radiomics-based machine learning models to predict response to infliximab in patients with Crohn's disease.Annals of medicine · 2025Article
- Dietary factors and nutritional guidelines for sarcopenia in older adults: a narrative review.Korean journal of community nutrition · 2025Review
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.