Evidence map›Paper›PMID 34575878›Full record

ReviewInternational journal of molecular sciences2021

Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment.

Chung-Chieh Hung, Chieh-Hsin Lin, Hsien-Yuan Lane

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Hydrogen sulfide/polysulfides signaling and neuronal diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Chung-Chieh HungInstitute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan.
Chieh-Hsin LinInstitute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan.
Hsien-Yuan LaneInstitute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0003-2162-8174
Asia University · TWChang Gung University · TWChina Medical University · TW

Funding

China Medical University Hospital DMR-109-246Ministry of Science and Technology, Taiwan MOST 108-2314-B-039-002; MOST 109-2622-B-039-001-CC2; MOST 109-2314-B-039-039-MY3National Health Research Institutes NHRI-EX109-10731NI
6 · The paper itself

Abstract

Glutamate, a crucial excitatory neurotransmitter, plays a major role in the modulation of schizophrenia's pathogenesis. New drug developments for schizophrenia have been prompted by the hypoglutamatergic hypothesis of schizophrenia. The cystine/glutamate antiporter system x

Indexed as

Disease SusceptibilityAnimalsAntiportersBiological TransportBiomarkersCystineDisease ManagementGlutamic AcidHumansNeuronsNeurotransmitter AgentsOxidative StressPrecision MedicineSchizophreniaSynaptic TransmissionAntiportersBiomarkersCystineGlutamic AcidNeurotransmitter Agentsbiomarkercystine/glutamate antiporterschizophreniasystem xc−

Identifiers

PMID34575878
PMCPMC8466274
OpenAlexW3198793481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.