Evidence map›Paper›PMID 34575866›Full record

ArticleInternational journal of molecular sciences2021

Myeloid Lineage Ablation of

Ismael Y Karkache, Jeyaram R Damodaran, David H H Molstad, Kim C Mansky, Elizabeth W Bradley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Musculoskeletal Development and Skeletal Pathophysiology's.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ismael Y KarkacheDepartment of Orthopedics, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Jeyaram R DamodaranDepartment of Orthopedics, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0825-5572
David H H MolstadDepartment of Orthopedics, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Kim C ManskyDivision of Orthodontics, Department of Developmental and Surgical Services, Institute for Virology, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2826-5030
Elizabeth W BradleyDepartment of Orthopedics, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8814-5524
University of Minnesota · US

Funding

Functions of the PH-Domain Leucine Rich Protein Phosphatase (Phlpp)1 in OsteoclastsR01AR072634 · NIAMS · UNIVERSITY OF MINNESOTA · PI BRADLEY, ELIZABETH W · 2017 to 2021
$1.7M
NIAMS NIH HHS AR072634NIAMS NIH HHS R01 AR072634
6 · The paper itself

Abstract

Prior work demonstrated that Phlpp1 deficiency alters trabecular bone mass and enhances M-CSF responsiveness, but the cell types and requirement of Phlpp1 for this effect were unclear. To understand the function of Phlpp1 within myeloid lineage cells, we crossed

Indexed as

Bone ResorptionAnimalsBone and BonesCell LineageCytoplasmFemaleFemurGene DeletionMacrophage Colony-Stimulating FactorMaleMiceMice, Inbred C57BLMice, KnockoutMyeloid CellsOsteoblastsOsteoclastsMacrophage Colony-Stimulating FactorPHLPP1 protein, mousePhosphoprotein PhosphatasesRANK LigandAktbone massERKMEKosteoclastosteoporosisPDZ domainPH domainProtein Kinase C (PKC)Ras-association domainsexual dimorphism

Identifiers

PMID34575866
PMCPMC8468863
OpenAlexW3198205110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.