Evidence map›Paper›PMID 34575846›Full record

ArticleInternational journal of molecular sciences2021

Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human

Jerzy Wiater, Marcin Samiec, Kamil Wartalski, Zdzisław Smorąg, Jacek Jura, Ryszard Słomski, Maria Skrzyszowska, Marek Romek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. DNA methylation regulates RNA mCell proliferation · 2024
    Article
  2. Article
  3. Article
  4. Perspectives in Genome-Editing Techniques for Livestock.Animals : an open access journal from MDPI · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Zoological research · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jerzy WiaterDepartment of Histology, Jagiellonian University Medical College, Kopernika 7 Street, 31-034 Kraków, Poland.ORCID 0000-0003-0911-3696
Marcin SamiecDepartment of Reproductive Biotechnology and Cryoconservation, National Research Institute of Animal Production, Krakowska 1 Street, 32-083 Balice near Kraków, Poland.ORCID 0000-0002-4060-1893
Kamil WartalskiDepartment of Histology, Jagiellonian University Medical College, Kopernika 7 Street, 31-034 Kraków, Poland.ORCID 0000-0002-4120-067X
Zdzisław SmorągDepartment of Reproductive Biotechnology and Cryoconservation, National Research Institute of Animal Production, Krakowska 1 Street, 32-083 Balice near Kraków, Poland.ORCID 0000-0003-1143-0885
Jacek JuraDepartment of Reproductive Biotechnology and Cryoconservation, National Research Institute of Animal Production, Krakowska 1 Street, 32-083 Balice near Kraków, Poland.ORCID 0000-0003-1544-1733
Ryszard SłomskiInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32 Street, 60-479 Poznań, Poland.ORCID 0000-0001-5601-7002
Maria SkrzyszowskaDepartment of Reproductive Biotechnology and Cryoconservation, National Research Institute of Animal Production, Krakowska 1 Street, 32-083 Balice near Kraków, Poland.ORCID 0000-0002-0068-6407
Marek RomekDepartment of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Gronostajowa 9 Street, 30-387 Kraków, Poland.ORCID 0000-0002-7631-081X
National Research Institute of Animal Production · PLJagiellonian University · PLInstitute of Human Genetics · PL

Funding

Ministry of Education and Science in Poland 04-19-05-00
6 · The paper itself

Abstract

Pig-to-human xenotransplantation seems to be the response to the contemporary shortage of tissue/organ donors. Unfortunately, the phylogenetic distance between pig and human implies hyperacute xenograft rejection. In this study, we tested the hypothesis that combining expression of human α1,2-fucosyltransferase (h

Indexed as

Gene Expressionalpha-GalactosidaseAnimalsAnimals, Genetically ModifiedCells, CulturedEpidermal CellsFluorescent Antibody TechniqueFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseHumansKeratinocytesRecombinant ProteinsSwinealpha-GalactosidaseFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGLA protein, humanRecombinant Proteinsepidermal keratinocyteGalα1→3Gal epitopegenetically modified pighuman α-1,2-fucosyltransferasehuman α-galactosidase A

Identifiers

PMID34575846
PMCPMC8469251
OpenAlexW3197908344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.